Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study.
Non-Hodgkin's Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence c...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297140&type=printable |
| _version_ | 1797279598854012928 |
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| author | Marcia Sarpa Vanessa Índio do Brasil da Costa Sâmila Natiane Ferreira Carolina Ávila de Almeida Paula Gabriela Sousa de Oliveira Letícia Vargas de Mesquita Arthur O C Schilithz Claudio Gustavo Stefanoff Rocio Hassan Ubirani Barros Otero |
| author_facet | Marcia Sarpa Vanessa Índio do Brasil da Costa Sâmila Natiane Ferreira Carolina Ávila de Almeida Paula Gabriela Sousa de Oliveira Letícia Vargas de Mesquita Arthur O C Schilithz Claudio Gustavo Stefanoff Rocio Hassan Ubirani Barros Otero |
| author_sort | Marcia Sarpa |
| collection | DOAJ |
| description | Non-Hodgkin's Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to any solvents, hydrocarbon solvents, pesticides, meat and meat products, and sunlight and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for any solvents and hydrocarbon solvents (NHL (any subtype) p-value for trend<0.001), B-cell lymphoma (p-value for trend<0.001), and T-cell lymphoma (p-value for trend<0.023), pesticides (NHL (any subtype), p for trend<0.001) and T-cell lymphoma (p for trend<0.002), meat and meat products (NHL (any subtype) (p for trend<0.001) and DLBCL (p for trend<0.001), and sunlight (B-cell lymphoma (p for trend<0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer. |
| first_indexed | 2024-03-07T16:28:27Z |
| format | Article |
| id | doaj.art-45b7e93032f045fa99468605198efff7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T16:28:27Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-45b7e93032f045fa99468605198efff72024-03-03T12:56:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029714010.1371/journal.pone.0297140Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study.Marcia SarpaVanessa Índio do Brasil da CostaSâmila Natiane FerreiraCarolina Ávila de AlmeidaPaula Gabriela Sousa de OliveiraLetícia Vargas de MesquitaArthur O C SchilithzClaudio Gustavo StefanoffRocio HassanUbirani Barros OteroNon-Hodgkin's Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to any solvents, hydrocarbon solvents, pesticides, meat and meat products, and sunlight and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for any solvents and hydrocarbon solvents (NHL (any subtype) p-value for trend<0.001), B-cell lymphoma (p-value for trend<0.001), and T-cell lymphoma (p-value for trend<0.023), pesticides (NHL (any subtype), p for trend<0.001) and T-cell lymphoma (p for trend<0.002), meat and meat products (NHL (any subtype) (p for trend<0.001) and DLBCL (p for trend<0.001), and sunlight (B-cell lymphoma (p for trend<0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297140&type=printable |
| spellingShingle | Marcia Sarpa Vanessa Índio do Brasil da Costa Sâmila Natiane Ferreira Carolina Ávila de Almeida Paula Gabriela Sousa de Oliveira Letícia Vargas de Mesquita Arthur O C Schilithz Claudio Gustavo Stefanoff Rocio Hassan Ubirani Barros Otero Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. PLoS ONE |
| title | Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. |
| title_full | Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. |
| title_fullStr | Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. |
| title_full_unstemmed | Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. |
| title_short | Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study. |
| title_sort | investigation of occupational risk factors for the development of non hodgkin s lymphoma in adults a hospital based case control study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297140&type=printable |
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