Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum
Background: Photosensitizing ability of compounds is implicated in singlet oxygen (1O2) generation, a ROS nonradical able to oxidize biomolecules affecting the cellular integrity, the increase in ROS levels derived in oxidative stress that is associated to the toxicity mechanisms of mycotoxins. Here...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Electronic Journal of Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0717345823000027 |
| _version_ | 1797867653041225728 |
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| author | César Espinoza César Francheschy Irene Lagunes Guillermo Mendoza Manuel E. Medina Ángel Trigos |
| author_facet | César Espinoza César Francheschy Irene Lagunes Guillermo Mendoza Manuel E. Medina Ángel Trigos |
| author_sort | César Espinoza |
| collection | DOAJ |
| description | Background: Photosensitizing ability of compounds is implicated in singlet oxygen (1O2) generation, a ROS nonradical able to oxidize biomolecules affecting the cellular integrity, the increase in ROS levels derived in oxidative stress that is associated to the toxicity mechanisms of mycotoxins. Herein, the photosensitizing ability to generate 1O2 of 5-methoxysterigmatocystin, a mycotoxin isolated from aquatic fungus Acremonium persicinum, was evaluated. Photosensitizing ability was determined through photo-oxidation of ergosterol method and corroborated by theoretical studies using Gaussian 16 programs, the M06-2X functional and the 6-311++G (d,p) basis set. Results: 5-methoxysterigmatocystin exhibited efficient photosensitizing ability because it transformed 100% of ergosterol into ergosterol peroxide. Theoretical studies confirmed the experimental results showing that 5-methoxysterigmatocystin satisfied the energy requirements and is able to generate 1O2 corroborating their photosensitizing ability. Conclusions: The identification of the photosensitizing ability of fungal compounds, such as 5-methoxysterigmatocystin and the use of visible light, could be useful in the implementation of fungi control strategies through the inactivation by self-destruction of fungi that produce photosensitizer mycotoxins in food and feed through the generation of 1O2 under light and thereby to contribute toward the improvement of food safety.How to cite: Espinoza C, Francheschy C, Lagunes I, et al. Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum. Electron J Biotechnol 2023;62. https://doi.org/10.1016/j.ejbt.2022.12.003. |
| first_indexed | 2024-04-09T23:43:33Z |
| format | Article |
| id | doaj.art-45b945a621ba4dbab17704bf7b7f5eba |
| institution | Directory Open Access Journal |
| issn | 0717-3458 |
| language | English |
| last_indexed | 2024-04-09T23:43:33Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Electronic Journal of Biotechnology |
| spelling | doaj.art-45b945a621ba4dbab17704bf7b7f5eba2023-03-18T04:40:22ZengElsevierElectronic Journal of Biotechnology0717-34582023-03-01622126Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinumCésar Espinoza0César Francheschy1Irene Lagunes2Guillermo Mendoza3Manuel E. Medina4Ángel Trigos5Centro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoCentro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoCentro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoCentro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoCentro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoCorresponding author.; Centro de Investigación en Micología Aplicada, Universidad Veracruzana, Médicos No. 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, MexicoBackground: Photosensitizing ability of compounds is implicated in singlet oxygen (1O2) generation, a ROS nonradical able to oxidize biomolecules affecting the cellular integrity, the increase in ROS levels derived in oxidative stress that is associated to the toxicity mechanisms of mycotoxins. Herein, the photosensitizing ability to generate 1O2 of 5-methoxysterigmatocystin, a mycotoxin isolated from aquatic fungus Acremonium persicinum, was evaluated. Photosensitizing ability was determined through photo-oxidation of ergosterol method and corroborated by theoretical studies using Gaussian 16 programs, the M06-2X functional and the 6-311++G (d,p) basis set. Results: 5-methoxysterigmatocystin exhibited efficient photosensitizing ability because it transformed 100% of ergosterol into ergosterol peroxide. Theoretical studies confirmed the experimental results showing that 5-methoxysterigmatocystin satisfied the energy requirements and is able to generate 1O2 corroborating their photosensitizing ability. Conclusions: The identification of the photosensitizing ability of fungal compounds, such as 5-methoxysterigmatocystin and the use of visible light, could be useful in the implementation of fungi control strategies through the inactivation by self-destruction of fungi that produce photosensitizer mycotoxins in food and feed through the generation of 1O2 under light and thereby to contribute toward the improvement of food safety.How to cite: Espinoza C, Francheschy C, Lagunes I, et al. Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum. Electron J Biotechnol 2023;62. https://doi.org/10.1016/j.ejbt.2022.12.003.http://www.sciencedirect.com/science/article/pii/S07173458230000275-methoxysterigmatocystinAcremonium persicinumAquatic fungusFungal compoundsMycotoxinOxidative stress |
| spellingShingle | César Espinoza César Francheschy Irene Lagunes Guillermo Mendoza Manuel E. Medina Ángel Trigos Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum Electronic Journal of Biotechnology 5-methoxysterigmatocystin Acremonium persicinum Aquatic fungus Fungal compounds Mycotoxin Oxidative stress |
| title | Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum |
| title_full | Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum |
| title_fullStr | Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum |
| title_full_unstemmed | Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum |
| title_short | Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum |
| title_sort | photosensitizer ability of 5 methoxysterigmatocystin isolated from aquatic fungus acremonium persicinum |
| topic | 5-methoxysterigmatocystin Acremonium persicinum Aquatic fungus Fungal compounds Mycotoxin Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S0717345823000027 |
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