Immunological role and prognostic value of SPARCL1 in pan-cancer analysis
Background: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 was strongly inhibited in most cancers. However, the potential functions of SPARCL1 in the pan-cancer cohort have not been widely studied.Methods: We evaluated the trans...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2022.1610687/full |
| _version_ | 1797218166534832128 |
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| author | Kangwei He Kangwei He Changjiu Li Hui Yuan Hui Yuan Kang Jiang Gang Deng |
| author_facet | Kangwei He Kangwei He Changjiu Li Hui Yuan Hui Yuan Kang Jiang Gang Deng |
| author_sort | Kangwei He |
| collection | DOAJ |
| description | Background: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 was strongly inhibited in most cancers. However, the potential functions of SPARCL1 in the pan-cancer cohort have not been widely studied.Methods: We evaluated the transcriptional level and the prognostic value of SPARCL1 in 33 types of cancer and revealed the relationship between genetic alterations of SPARCL1 and the tumor mutation burden. Meanwhile, we assessed the correlations between SPARCL1 and tumor-infiltrating lymphocytes across cancers.Results: The transcriptional level of SPARCL1 was inhibited in most cancers. Although SPARCL1 was down-regulated in most cancers, SPARCL1 might play a protective or detrimental role in different cancers. We demonstrated that mutation count was elevated in the altered SPARCL1 group in several cancers. Additionally, we found a significant positive correlation between SPARCL1 and macrophage infiltration levels in most cancers. Especially, marker sets of M2 macrophages were strongly related to SPARCL1 in cholangiocarcinoma, colon adenocarcinoma, rectum adenocarcinoma, and pancreatic adenocarcinoma.Conclusion: Our study found that SPARCL1 might work as a biomarker for prognosis and immune infiltration in pan-cancer analysis. |
| first_indexed | 2024-04-24T12:13:26Z |
| format | Article |
| id | doaj.art-45bec5bf728f4322b9acbc1da2cb8d31 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:13:26Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-45bec5bf728f4322b9acbc1da2cb8d312024-04-08T09:32:16ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072022-11-012810.3389/pore.2022.16106871610687Immunological role and prognostic value of SPARCL1 in pan-cancer analysisKangwei He0Kangwei He1Changjiu Li2Hui Yuan3Hui Yuan4Kang Jiang5Gang Deng6The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Urology Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Urology Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Urology Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Urology Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Urology Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackground: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 was strongly inhibited in most cancers. However, the potential functions of SPARCL1 in the pan-cancer cohort have not been widely studied.Methods: We evaluated the transcriptional level and the prognostic value of SPARCL1 in 33 types of cancer and revealed the relationship between genetic alterations of SPARCL1 and the tumor mutation burden. Meanwhile, we assessed the correlations between SPARCL1 and tumor-infiltrating lymphocytes across cancers.Results: The transcriptional level of SPARCL1 was inhibited in most cancers. Although SPARCL1 was down-regulated in most cancers, SPARCL1 might play a protective or detrimental role in different cancers. We demonstrated that mutation count was elevated in the altered SPARCL1 group in several cancers. Additionally, we found a significant positive correlation between SPARCL1 and macrophage infiltration levels in most cancers. Especially, marker sets of M2 macrophages were strongly related to SPARCL1 in cholangiocarcinoma, colon adenocarcinoma, rectum adenocarcinoma, and pancreatic adenocarcinoma.Conclusion: Our study found that SPARCL1 might work as a biomarker for prognosis and immune infiltration in pan-cancer analysis.https://www.por-journal.com/articles/10.3389/pore.2022.1610687/fullprognosisimmune infiltrationpan-cancerSPARCL1M2 macrophage |
| spellingShingle | Kangwei He Kangwei He Changjiu Li Hui Yuan Hui Yuan Kang Jiang Gang Deng Immunological role and prognostic value of SPARCL1 in pan-cancer analysis Pathology and Oncology Research prognosis immune infiltration pan-cancer SPARCL1 M2 macrophage |
| title | Immunological role and prognostic value of SPARCL1 in pan-cancer analysis |
| title_full | Immunological role and prognostic value of SPARCL1 in pan-cancer analysis |
| title_fullStr | Immunological role and prognostic value of SPARCL1 in pan-cancer analysis |
| title_full_unstemmed | Immunological role and prognostic value of SPARCL1 in pan-cancer analysis |
| title_short | Immunological role and prognostic value of SPARCL1 in pan-cancer analysis |
| title_sort | immunological role and prognostic value of sparcl1 in pan cancer analysis |
| topic | prognosis immune infiltration pan-cancer SPARCL1 M2 macrophage |
| url | https://www.por-journal.com/articles/10.3389/pore.2022.1610687/full |
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