Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds

INTRODUCTION: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. A group of patients who were admitted with PHPT and had normal calcium levels with high parathyroid hormone (PTH) levels was defined as normocalcemic PHPT (NPHPT). The data of PHPT operated patients were retr...

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Main Author: Şefika Burçak Polat
Format: Article
Language:English
Published: Ankara Yildirim Beyazit University 2022-06-01
Series:Ankara Medical Journal
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-82231
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author Şefika Burçak Polat
author_facet Şefika Burçak Polat
author_sort Şefika Burçak Polat
collection DOAJ
description INTRODUCTION: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. A group of patients who were admitted with PHPT and had normal calcium levels with high parathyroid hormone (PTH) levels was defined as normocalcemic PHPT (NPHPT). The data of PHPT operated patients were retrospectively analyzed, and biochemical and clinical characteristics of hypercalcemic and normocalcemic patients were compared. METHODS: The data of patients diagnosed with PHPT between January 2012 and January 2019 were retrospectively evaluated. A total of 318 patients were divided into two subgroups, hypercalcemic and normocalcemic, according to their calcium level. The two groups were compared regarding clinical and biochemical properties. RESULTS: Female gender was dominant in both groups (P = 0.072). The mean age was similar in both groups (P = 0.362). As expected, serum corrected calcium (Ca), PTH levels, and urinary Ca excretion were higher in the hypercalcemia group (P < 0.001). There was no difference between the two groups in alkaline phosphatase, creatinine, and vitamin D levels. The percentage of localization with preoperative was similar. Also, there was no difference in adenoma features (echogenicity, cystic appearance) and localization on ultrasonography (US). The positive result obtained on neck MRI and MIBI scanning was similar. There was no difference between the two groups in terms of kidney stone and osteoporosis prevalence DISCUSSION AND CONCLUSION: In our cohort, the NHPT phenotype was found to be like the hypercalcemic group. These findings suggest that the frequency of surgical indications is similar.
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spelling doaj.art-45c22b56b1054b0d8ada94f59cdfd1482023-02-15T16:08:57ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702022-06-0122223924810.5505/amj.2022.82231AMJ-82231Normocalcemic Primary Hyperparathyroidism is not innocent as it soundsŞefika Burçak Polat0Ankara Yildirim Beyazit University, Ankara City Hospital, Endocrinology and Metabolism DepartmentINTRODUCTION: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. A group of patients who were admitted with PHPT and had normal calcium levels with high parathyroid hormone (PTH) levels was defined as normocalcemic PHPT (NPHPT). The data of PHPT operated patients were retrospectively analyzed, and biochemical and clinical characteristics of hypercalcemic and normocalcemic patients were compared. METHODS: The data of patients diagnosed with PHPT between January 2012 and January 2019 were retrospectively evaluated. A total of 318 patients were divided into two subgroups, hypercalcemic and normocalcemic, according to their calcium level. The two groups were compared regarding clinical and biochemical properties. RESULTS: Female gender was dominant in both groups (P = 0.072). The mean age was similar in both groups (P = 0.362). As expected, serum corrected calcium (Ca), PTH levels, and urinary Ca excretion were higher in the hypercalcemia group (P < 0.001). There was no difference between the two groups in alkaline phosphatase, creatinine, and vitamin D levels. The percentage of localization with preoperative was similar. Also, there was no difference in adenoma features (echogenicity, cystic appearance) and localization on ultrasonography (US). The positive result obtained on neck MRI and MIBI scanning was similar. There was no difference between the two groups in terms of kidney stone and osteoporosis prevalence DISCUSSION AND CONCLUSION: In our cohort, the NHPT phenotype was found to be like the hypercalcemic group. These findings suggest that the frequency of surgical indications is similar.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-82231primary hyperparathyroidismnormocalcemic primary hyperparathyroidismcomplications.
spellingShingle Şefika Burçak Polat
Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
Ankara Medical Journal
primary hyperparathyroidism
normocalcemic primary hyperparathyroidism
complications.
title Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
title_full Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
title_fullStr Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
title_full_unstemmed Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
title_short Normocalcemic Primary Hyperparathyroidism is not innocent as it sounds
title_sort normocalcemic primary hyperparathyroidism is not innocent as it sounds
topic primary hyperparathyroidism
normocalcemic primary hyperparathyroidism
complications.
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-82231
work_keys_str_mv AT sefikaburcakpolat normocalcemicprimaryhyperparathyroidismisnotinnocentasitsounds