Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries
Abstract Introduction Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause‐specific mortality in global reports. Methods We analyzed global PE‐related mortality by focusing on the latest year available for each member state in the World Health Organization (WH...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | https://doi.org/10.1002/rth2.12520 |
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| author | Stefano Barco Luca Valerio Andrea Gallo Giacomo Turatti Seyed Hamidreza Mahmoudpour Walter Ageno Lana A. Castellucci Gabriela Cesarman‐Maus Henry Ddungu Erich Vinicius De Paula Mert Dumantepe Samuel Z. Goldhaber Maria Cecilia Guillermo Esposito Frederikus A. Klok Nils Kucher Claire McLintock Fionnuala Ní Áinle Paolo Simioni David Spirk Alex C. Spyropoulos Tetsumei Urano Zhen‐guo Zhai Beverley J. Hunt Stavros V. Konstantinides |
| author_facet | Stefano Barco Luca Valerio Andrea Gallo Giacomo Turatti Seyed Hamidreza Mahmoudpour Walter Ageno Lana A. Castellucci Gabriela Cesarman‐Maus Henry Ddungu Erich Vinicius De Paula Mert Dumantepe Samuel Z. Goldhaber Maria Cecilia Guillermo Esposito Frederikus A. Klok Nils Kucher Claire McLintock Fionnuala Ní Áinle Paolo Simioni David Spirk Alex C. Spyropoulos Tetsumei Urano Zhen‐guo Zhai Beverley J. Hunt Stavros V. Konstantinides |
| author_sort | Stefano Barco |
| collection | DOAJ |
| description | Abstract Introduction Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause‐specific mortality in global reports. Methods We analyzed global PE‐related mortality by focusing on the latest year available for each member state in the World Health Organization (WHO) mortality database, which provides age‐sex–specific aggregated mortality data transmitted by national authorities for each underlying cause of death. PE‐related deaths were defined by International Classification of Diseases, Tenth Revision codes for acute PE or nonfatal manifestations of venous thromboembolism (VTE). The 2001 WHO standard population served for standardization. Results We obtained data from 123 countries covering a total population of 2 602 561 422. Overall, 50 (40.6%) were European, 39 (31.7%) American, 13 (10.6%) Eastern Mediterranean, 13 (10.6%) Western Pacific, 3 (2.4%) Southeast Asian, and 2 (1.6%) African. Of 116 countries classifiable according to population income, 57 (49.1%) were high income, 42 (36.2%) upper‐middle income, 14 (12.1%) lower‐middle income, and 3 (2.6%) low income. A total of 18 726 382 deaths were recorded, of which 86 930 (0.46%) were attributed to PE. PE‐related mortality rate increased with age in most countries. The reporting of PE‐related deaths was heterogeneous, with an age‐standardized mortality rate ranging from 0 to 24 deaths per 100 000 population‐years. Income status only partially explained this heterogeneity. Conclusions Reporting of PE‐related mortality in official national vital registration was characterized by extreme heterogeneity across countries. These findings mandate enhanced efforts toward systematic and uniform coverage of PE‐related mortality and provides a case for full recognition of PE and VTE as a primary cause of death. |
| first_indexed | 2024-03-12T04:41:47Z |
| format | Article |
| id | doaj.art-45c3ebd6930844a480b634267d88327d |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T04:41:47Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-45c3ebd6930844a480b634267d88327d2023-09-03T09:34:39ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792021-07-0155n/an/a10.1002/rth2.12520Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countriesStefano Barco0Luca Valerio1Andrea Gallo2Giacomo Turatti3Seyed Hamidreza Mahmoudpour4Walter Ageno5Lana A. Castellucci6Gabriela Cesarman‐Maus7Henry Ddungu8Erich Vinicius De Paula9Mert Dumantepe10Samuel Z. Goldhaber11Maria Cecilia Guillermo Esposito12Frederikus A. Klok13Nils Kucher14Claire McLintock15Fionnuala Ní Áinle16Paolo Simioni17David Spirk18Alex C. Spyropoulos19Tetsumei Urano20Zhen‐guo Zhai21Beverley J. Hunt22Stavros V. Konstantinides23Clinic of Angiology University Hospital Zurich Zurich SwitzerlandCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyDepartment of Medicine and Surgery University of Insubria Varese ItalyDepartment of Medicine Faculty of Medicine Ottawa Hospital Research Institute University of Ottawa Ottawa ON CanadaDepartment of Hematology Instituto Nacional de Cancerología Mexico City MexicoUganda Cancer Institute Kampala UgandaSchool of Medical Sciences University of Campinas Campinas SP BrazilDepartment of Cardiovascular Surgery Florence Nightingale Hospital Istanbul TurkeyDivision of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USADepartment of Hematology Hospital de Clinicas Facultad de Medicina Universidad de la República Montevideo Montevideo UruguayCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyClinic of Angiology University Hospital Zurich Zurich SwitzerlandNational Women’s Health Auckland City Hospital Auckland New ZealandDepartment of Haematology Mater Misericordiae University Hospital Dublin IrelandGeneral Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit Department of Medicine University of Padua Medical School Padua ItalyInstitute of Pharmacology University of Bern Bern SwitzerlandDonald and Barbara Zucker School of Medicine at Hofstra/Northwell and Institute for Health Innovations and Outcomes Research Feinstein Institutes for Medical Research Manhasset NY USADepartment of Medical Physiology Hamamatsu University School of Medicine Hamamatsu JapanDepartment of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China‐Japan Friendship Hospital Institute of Respiratory Medicine Chinese Academy of Medical Sciences National Clinical Research Center for Respiratory Diseases Beijing ChinaThrombosis & Haemophilia Centre Guys & St Thomas’ NHS Foundation Trust London UKCenter for Thrombosis and Hemostasis University Medical Center Mainz Mainz GermanyAbstract Introduction Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause‐specific mortality in global reports. Methods We analyzed global PE‐related mortality by focusing on the latest year available for each member state in the World Health Organization (WHO) mortality database, which provides age‐sex–specific aggregated mortality data transmitted by national authorities for each underlying cause of death. PE‐related deaths were defined by International Classification of Diseases, Tenth Revision codes for acute PE or nonfatal manifestations of venous thromboembolism (VTE). The 2001 WHO standard population served for standardization. Results We obtained data from 123 countries covering a total population of 2 602 561 422. Overall, 50 (40.6%) were European, 39 (31.7%) American, 13 (10.6%) Eastern Mediterranean, 13 (10.6%) Western Pacific, 3 (2.4%) Southeast Asian, and 2 (1.6%) African. Of 116 countries classifiable according to population income, 57 (49.1%) were high income, 42 (36.2%) upper‐middle income, 14 (12.1%) lower‐middle income, and 3 (2.6%) low income. A total of 18 726 382 deaths were recorded, of which 86 930 (0.46%) were attributed to PE. PE‐related mortality rate increased with age in most countries. The reporting of PE‐related deaths was heterogeneous, with an age‐standardized mortality rate ranging from 0 to 24 deaths per 100 000 population‐years. Income status only partially explained this heterogeneity. Conclusions Reporting of PE‐related mortality in official national vital registration was characterized by extreme heterogeneity across countries. These findings mandate enhanced efforts toward systematic and uniform coverage of PE‐related mortality and provides a case for full recognition of PE and VTE as a primary cause of death.https://doi.org/10.1002/rth2.12520epidemiologymortalitypulmonary embolismvenous thromboembolismWorld Health Organization |
| spellingShingle | Stefano Barco Luca Valerio Andrea Gallo Giacomo Turatti Seyed Hamidreza Mahmoudpour Walter Ageno Lana A. Castellucci Gabriela Cesarman‐Maus Henry Ddungu Erich Vinicius De Paula Mert Dumantepe Samuel Z. Goldhaber Maria Cecilia Guillermo Esposito Frederikus A. Klok Nils Kucher Claire McLintock Fionnuala Ní Áinle Paolo Simioni David Spirk Alex C. Spyropoulos Tetsumei Urano Zhen‐guo Zhai Beverley J. Hunt Stavros V. Konstantinides Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries Research and Practice in Thrombosis and Haemostasis epidemiology mortality pulmonary embolism venous thromboembolism World Health Organization |
| title | Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries |
| title_full | Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries |
| title_fullStr | Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries |
| title_full_unstemmed | Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries |
| title_short | Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: Vital registration data from 123 countries |
| title_sort | global reporting of pulmonary embolism related deaths in the world health organization mortality database vital registration data from 123 countries |
| topic | epidemiology mortality pulmonary embolism venous thromboembolism World Health Organization |
| url | https://doi.org/10.1002/rth2.12520 |
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