Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities
Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4418/8/1/2 |
| _version_ | 1798041196237422592 |
|---|---|
| author | Fabio Nery Isky Gordon David L. Thomas |
| author_facet | Fabio Nery Isky Gordon David L. Thomas |
| author_sort | Fabio Nery |
| collection | DOAJ |
| description | Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL), a magnetic resonance imaging (MRI) technique, is arguably the only available method with potential to meet all these needs. Recent developments suggest its viability for clinical application. This review addresses several of these developments and discusses remaining challenges with the emphasis on renal imaging in human subjects. |
| first_indexed | 2024-04-11T22:18:07Z |
| format | Article |
| id | doaj.art-45c6694ae7d047fba6cc52829e0e5206 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-11T22:18:07Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-45c6694ae7d047fba6cc52829e0e52062022-12-22T04:00:19ZengMDPI AGDiagnostics2075-44182018-01-0181210.3390/diagnostics8010002diagnostics8010002Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and OpportunitiesFabio Nery0Isky Gordon1David L. Thomas2Developmental Imaging & Biophysics Section, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UKDevelopmental Imaging & Biophysics Section, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UKDepartment of Brain Repair and Rehabilitation, University College London Institute of Neurology, London WC1N 3BG, UKTissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL), a magnetic resonance imaging (MRI) technique, is arguably the only available method with potential to meet all these needs. Recent developments suggest its viability for clinical application. This review addresses several of these developments and discusses remaining challenges with the emphasis on renal imaging in human subjects.http://www.mdpi.com/2075-4418/8/1/2magnetic resonance imagingarterial spin labelingrenal MRIrenal ASLchronic kidney diseasekidney perfusion |
| spellingShingle | Fabio Nery Isky Gordon David L. Thomas Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities Diagnostics magnetic resonance imaging arterial spin labeling renal MRI renal ASL chronic kidney disease kidney perfusion |
| title | Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities |
| title_full | Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities |
| title_fullStr | Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities |
| title_full_unstemmed | Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities |
| title_short | Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities |
| title_sort | non invasive renal perfusion imaging using arterial spin labeling mri challenges and opportunities |
| topic | magnetic resonance imaging arterial spin labeling renal MRI renal ASL chronic kidney disease kidney perfusion |
| url | http://www.mdpi.com/2075-4418/8/1/2 |
| work_keys_str_mv | AT fabionery noninvasiverenalperfusionimagingusingarterialspinlabelingmrichallengesandopportunities AT iskygordon noninvasiverenalperfusionimagingusingarterialspinlabelingmrichallengesandopportunities AT davidlthomas noninvasiverenalperfusionimagingusingarterialspinlabelingmrichallengesandopportunities |