Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications
Crystallization alters the characteristics of TiO<sub>2</sub> nanosurfaces, which consequently influences their bio-performance. In various biomedical applications, the anatase or rutile crystal phase is preferred over amorphous TiO<sub>2</sub>. The most common crystallizatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/6/1121 |
| _version_ | 1797565920050151424 |
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| author | Metka Benčina Aleš Iglič Miran Mozetič Ita Junkar |
| author_facet | Metka Benčina Aleš Iglič Miran Mozetič Ita Junkar |
| author_sort | Metka Benčina |
| collection | DOAJ |
| description | Crystallization alters the characteristics of TiO<sub>2</sub> nanosurfaces, which consequently influences their bio-performance. In various biomedical applications, the anatase or rutile crystal phase is preferred over amorphous TiO<sub>2</sub>. The most common crystallization technique is annealing in a conventional furnace. Methods such as hydrothermal or room temperature crystallization, as well as plasma electrolytic oxidation (PEO) and other plasma-induced crystallization techniques, present more feasible and rapid alternatives for crystal phase initiation or transition between anatase and rutile phases. With oxygen plasma treatment, it is possible to achieve an anatase or rutile crystal phase in a few seconds, depending on the plasma conditions. This review article aims to address different crystallization techniques on nanostructured TiO<sub>2</sub> surfaces and the influence of crystal phase on biological response. The emphasis is given to electrochemically anodized nanotube arrays and their interaction with the biological environment. A short overview of the most commonly employed medical devices made of titanium and its alloys is presented and discussed. |
| first_indexed | 2024-03-10T19:19:44Z |
| format | Article |
| id | doaj.art-45c66cc266144e49b98146e08e9063e3 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T19:19:44Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-45c66cc266144e49b98146e08e9063e32023-11-20T03:05:21ZengMDPI AGNanomaterials2079-49912020-06-01106112110.3390/nano10061121Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical ApplicationsMetka Benčina0Aleš Iglič1Miran Mozetič2Ita Junkar3Department of Surface Engineering and Optoelectronics, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, SloveniaLaboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1000 Ljubljana, SloveniaDepartment of Surface Engineering and Optoelectronics, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, SloveniaDepartment of Surface Engineering and Optoelectronics, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, SloveniaCrystallization alters the characteristics of TiO<sub>2</sub> nanosurfaces, which consequently influences their bio-performance. In various biomedical applications, the anatase or rutile crystal phase is preferred over amorphous TiO<sub>2</sub>. The most common crystallization technique is annealing in a conventional furnace. Methods such as hydrothermal or room temperature crystallization, as well as plasma electrolytic oxidation (PEO) and other plasma-induced crystallization techniques, present more feasible and rapid alternatives for crystal phase initiation or transition between anatase and rutile phases. With oxygen plasma treatment, it is possible to achieve an anatase or rutile crystal phase in a few seconds, depending on the plasma conditions. This review article aims to address different crystallization techniques on nanostructured TiO<sub>2</sub> surfaces and the influence of crystal phase on biological response. The emphasis is given to electrochemically anodized nanotube arrays and their interaction with the biological environment. A short overview of the most commonly employed medical devices made of titanium and its alloys is presented and discussed.https://www.mdpi.com/2079-4991/10/6/1121titanium oxidenanostructurecrystalline phasebiocompatibilitysurface modification |
| spellingShingle | Metka Benčina Aleš Iglič Miran Mozetič Ita Junkar Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications Nanomaterials titanium oxide nanostructure crystalline phase biocompatibility surface modification |
| title | Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications |
| title_full | Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications |
| title_fullStr | Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications |
| title_full_unstemmed | Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications |
| title_short | Crystallized TiO<sub>2</sub> Nanosurfaces in Biomedical Applications |
| title_sort | crystallized tio sub 2 sub nanosurfaces in biomedical applications |
| topic | titanium oxide nanostructure crystalline phase biocompatibility surface modification |
| url | https://www.mdpi.com/2079-4991/10/6/1121 |
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