Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
Despite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00617/full |
| _version_ | 1811216365733806080 |
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| author | Mark Gray James Meehan Carlos Martínez-Pérez Charlene Kay Arran K. Turnbull Linda R. Morrison Lisa Y. Pang David Argyle |
| author_facet | Mark Gray James Meehan Carlos Martínez-Pérez Charlene Kay Arran K. Turnbull Linda R. Morrison Lisa Y. Pang David Argyle |
| author_sort | Mark Gray |
| collection | DOAJ |
| description | Despite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from localized disease has improved significantly, the prognosis for patients diagnosed with metastatic disease remains poor with 5-year survival rates at only 25%. In vitro studies using immortalized cell lines and in vivo mouse models, typically using xenografted cell lines or patient derived material, are commonly used to study breast cancer. Although these techniques have undoubtedly increased our molecular understanding of breast cancer, these research models have significant limitations and have contributed to the high attrition rates seen in cancer drug discovery. It is estimated that only 3–6% of drugs that show promise in these pre-clinical models will reach clinical use. Models that can reproduce human breast cancer more accurately are needed if significant advances are to be achieved in improving cancer drug research, treatment outcomes, and prognosis. Canine mammary tumors are a naturally-occurring heterogenous group of cancers that have several features in common with human breast cancer. These similarities include etiology, signaling pathway activation and histological classification. In this review article we discuss the use of naturally-occurring canine mammary tumors as a translational animal model for human breast cancer research. |
| first_indexed | 2024-04-12T06:37:52Z |
| format | Article |
| id | doaj.art-45c6cc0aec4d4be6b4e8d351cf46508a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T06:37:52Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-45c6cc0aec4d4be6b4e8d351cf46508a2022-12-22T03:43:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00617528940Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast CancerMark Gray0James Meehan1Carlos Martínez-Pérez2Charlene Kay3Arran K. Turnbull4Linda R. Morrison5Lisa Y. Pang6David Argyle7The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United KingdomTranslational Oncology Research Group, Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomTranslational Oncology Research Group, Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomTranslational Oncology Research Group, Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomTranslational Oncology Research Group, Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United KingdomThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United KingdomThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United KingdomDespite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from localized disease has improved significantly, the prognosis for patients diagnosed with metastatic disease remains poor with 5-year survival rates at only 25%. In vitro studies using immortalized cell lines and in vivo mouse models, typically using xenografted cell lines or patient derived material, are commonly used to study breast cancer. Although these techniques have undoubtedly increased our molecular understanding of breast cancer, these research models have significant limitations and have contributed to the high attrition rates seen in cancer drug discovery. It is estimated that only 3–6% of drugs that show promise in these pre-clinical models will reach clinical use. Models that can reproduce human breast cancer more accurately are needed if significant advances are to be achieved in improving cancer drug research, treatment outcomes, and prognosis. Canine mammary tumors are a naturally-occurring heterogenous group of cancers that have several features in common with human breast cancer. These similarities include etiology, signaling pathway activation and histological classification. In this review article we discuss the use of naturally-occurring canine mammary tumors as a translational animal model for human breast cancer research.https://www.frontiersin.org/article/10.3389/fonc.2020.00617/fullcanine mammary cancercomparative oncologyhuman breast cancerin vivo modelstranslational models |
| spellingShingle | Mark Gray James Meehan Carlos Martínez-Pérez Charlene Kay Arran K. Turnbull Linda R. Morrison Lisa Y. Pang David Argyle Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer Frontiers in Oncology canine mammary cancer comparative oncology human breast cancer in vivo models translational models |
| title | Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer |
| title_full | Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer |
| title_fullStr | Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer |
| title_full_unstemmed | Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer |
| title_short | Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer |
| title_sort | naturally occurring canine mammary tumors as a translational model for human breast cancer |
| topic | canine mammary cancer comparative oncology human breast cancer in vivo models translational models |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00617/full |
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