Cellular crosstalk in atherosclerotic plaque microenvironment
Abstract Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01153-w |
| _version_ | 1827933244447784960 |
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| author | Elmira Mahdinia Nafiseh Shokri Abdolkarim Talebi Taheri Sahar Asgharzadeh Mohammad Elahimanesh Mohammad Najafi |
| author_facet | Elmira Mahdinia Nafiseh Shokri Abdolkarim Talebi Taheri Sahar Asgharzadeh Mohammad Elahimanesh Mohammad Najafi |
| author_sort | Elmira Mahdinia |
| collection | DOAJ |
| description | Abstract Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment, cell polarization, and cell fat droplets. It also describes cross talking between endothelial cells, macrophages, and vascular smooth muscle cells, as well as the cellular pathways involved in plaque development in the plaque microenvironment. Finally, it describes the plaque structural components and the role of factors involved in the rupture and erosion of plaques in the vessel. Video Abstract |
| first_indexed | 2024-03-13T07:22:05Z |
| format | Article |
| id | doaj.art-45c721fc28e04a0a8fe365d1850c7ce1 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-13T07:22:05Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-45c721fc28e04a0a8fe365d1850c7ce12023-06-04T11:34:34ZengBMCCell Communication and Signaling1478-811X2023-05-0121111610.1186/s12964-023-01153-wCellular crosstalk in atherosclerotic plaque microenvironmentElmira Mahdinia0Nafiseh Shokri1Abdolkarim Talebi Taheri2Sahar Asgharzadeh3Mohammad Elahimanesh4Mohammad Najafi5Department of Clinical Biochemistry, School of Medicine, Iran University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Iran University of Medical SciencesDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Clinical Biochemistry, Faculty of Medicine, Ghazvin University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Iran University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Iran University of Medical SciencesAbstract Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved in the formation, growth and remodeling of plaque, including the cell recruitment, cell polarization, and cell fat droplets. It also describes cross talking between endothelial cells, macrophages, and vascular smooth muscle cells, as well as the cellular pathways involved in plaque development in the plaque microenvironment. Finally, it describes the plaque structural components and the role of factors involved in the rupture and erosion of plaques in the vessel. Video Abstracthttps://doi.org/10.1186/s12964-023-01153-wAtherosclerosisPolarizationPlaqueRuptureErosion |
| spellingShingle | Elmira Mahdinia Nafiseh Shokri Abdolkarim Talebi Taheri Sahar Asgharzadeh Mohammad Elahimanesh Mohammad Najafi Cellular crosstalk in atherosclerotic plaque microenvironment Cell Communication and Signaling Atherosclerosis Polarization Plaque Rupture Erosion |
| title | Cellular crosstalk in atherosclerotic plaque microenvironment |
| title_full | Cellular crosstalk in atherosclerotic plaque microenvironment |
| title_fullStr | Cellular crosstalk in atherosclerotic plaque microenvironment |
| title_full_unstemmed | Cellular crosstalk in atherosclerotic plaque microenvironment |
| title_short | Cellular crosstalk in atherosclerotic plaque microenvironment |
| title_sort | cellular crosstalk in atherosclerotic plaque microenvironment |
| topic | Atherosclerosis Polarization Plaque Rupture Erosion |
| url | https://doi.org/10.1186/s12964-023-01153-w |
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