Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling
<i>Background and Objectives:</i> Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the progno...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/10/1426 |
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| author | Sarah Sabrina Zakaria Anand Ramanathan Zakiah Mat Ripen Wan Maria Nabillah Ghani Yi-Hsin Yang Vui King Vincent-Chong Siti Mazlipah Ismail |
| author_facet | Sarah Sabrina Zakaria Anand Ramanathan Zakiah Mat Ripen Wan Maria Nabillah Ghani Yi-Hsin Yang Vui King Vincent-Chong Siti Mazlipah Ismail |
| author_sort | Sarah Sabrina Zakaria |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment inflammatory markers in patients with OSCC. <i>Materials and Methods:</i> In this retrospective analysis, information on 151 OSCC patients’ socio-demographic, clinico-pathological, recurrence, metastasis, and survival data were gathered from clinical records. A multivariable Cox proportional hazards regression (stepwise model) was conducted to identify the prognostic predictors of OS and DFS. The multivariable models’ performances were evaluated using Harrell’s concordance statistics. <i>Results:</i> For OS, high pre-treatment LMR (HR 3.06, 95%CI 1.56, 5.99), and high post-treatment PLC (HR 3.35, 95%CI 1.71, 6.54) and PLR (HR 5.26, 95%CI 2.62, 10.58) were indicative of a poor prognosis. For DFS, high pre-treatment SII (HR 2.59, 95%CI 1.50, 4.48) and high post-treatment PLC (HR 1.92, 95%CI 1.11, 3.32) and PLR (HR 3.44, 95%CI 1.98, 5.07) were associated with increased mortality. The fitness of the OS and DFS stepwise Cox regression models were proven with a time-dependent AUC of 0.8787 and 0.8502, respectively. <i>Conclusions:</i> High pre-treatment levels of LMR and SII and high post-treatment levels of PLC and PLR are independent predictors of a poor prognosis for patients with OSCC. |
| first_indexed | 2024-03-09T19:51:04Z |
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| language | English |
| last_indexed | 2024-03-09T19:51:04Z |
| publishDate | 2022-10-01 |
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| series | Medicina |
| spelling | doaj.art-45c73055818a4075ab227c89a7f7f2732023-11-24T01:10:54ZengMDPI AGMedicina1010-660X1648-91442022-10-015810142610.3390/medicina58101426Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise ModellingSarah Sabrina Zakaria0Anand Ramanathan1Zakiah Mat Ripen2Wan Maria Nabillah Ghani3Yi-Hsin Yang4Vui King Vincent-Chong5Siti Mazlipah Ismail6Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur 50603, MalaysiaOral Cancer Research & Coordinating Centre, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur 50603, MalaysiaNational Institute of Cancer Research, National Health Research Institutes, Tainan 70456, TaiwanDepartment of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur 50603, Malaysia<i>Background and Objectives:</i> Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment inflammatory markers in patients with OSCC. <i>Materials and Methods:</i> In this retrospective analysis, information on 151 OSCC patients’ socio-demographic, clinico-pathological, recurrence, metastasis, and survival data were gathered from clinical records. A multivariable Cox proportional hazards regression (stepwise model) was conducted to identify the prognostic predictors of OS and DFS. The multivariable models’ performances were evaluated using Harrell’s concordance statistics. <i>Results:</i> For OS, high pre-treatment LMR (HR 3.06, 95%CI 1.56, 5.99), and high post-treatment PLC (HR 3.35, 95%CI 1.71, 6.54) and PLR (HR 5.26, 95%CI 2.62, 10.58) were indicative of a poor prognosis. For DFS, high pre-treatment SII (HR 2.59, 95%CI 1.50, 4.48) and high post-treatment PLC (HR 1.92, 95%CI 1.11, 3.32) and PLR (HR 3.44, 95%CI 1.98, 5.07) were associated with increased mortality. The fitness of the OS and DFS stepwise Cox regression models were proven with a time-dependent AUC of 0.8787 and 0.8502, respectively. <i>Conclusions:</i> High pre-treatment levels of LMR and SII and high post-treatment levels of PLC and PLR are independent predictors of a poor prognosis for patients with OSCC.https://www.mdpi.com/1648-9144/58/10/1426inflammatory markersoral squamous cell carcinomaprognosisoverall survivaldisease-free survival |
| spellingShingle | Sarah Sabrina Zakaria Anand Ramanathan Zakiah Mat Ripen Wan Maria Nabillah Ghani Yi-Hsin Yang Vui King Vincent-Chong Siti Mazlipah Ismail Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling Medicina inflammatory markers oral squamous cell carcinoma prognosis overall survival disease-free survival |
| title | Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling |
| title_full | Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling |
| title_fullStr | Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling |
| title_full_unstemmed | Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling |
| title_short | Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling |
| title_sort | prognostic abilities of pre and post treatment inflammatory markers in oral squamous cell carcinoma stepwise modelling |
| topic | inflammatory markers oral squamous cell carcinoma prognosis overall survival disease-free survival |
| url | https://www.mdpi.com/1648-9144/58/10/1426 |
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