Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report
A 78-year-old woman with severe auditory disturbance was referred to our hospital and was diagnosed with otitis media with anti-neutrophil cytoplasmic antibody -associated vasculitis (OMAAV). The auditory disturbance improved moderately with prednisolone 40 mg/day, but multiple pulmonary masses were...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007122001939 |
| _version_ | 1811316206022426624 |
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| author | Hirokazu Tokuyasu Saaya Hosoda Yuriko Sueda Hiromitsu Sakai Natsumi Omura-Tanaka Hiroshi Miura Ryota Okazaki Akira Yamasaki |
| author_facet | Hirokazu Tokuyasu Saaya Hosoda Yuriko Sueda Hiromitsu Sakai Natsumi Omura-Tanaka Hiroshi Miura Ryota Okazaki Akira Yamasaki |
| author_sort | Hirokazu Tokuyasu |
| collection | DOAJ |
| description | A 78-year-old woman with severe auditory disturbance was referred to our hospital and was diagnosed with otitis media with anti-neutrophil cytoplasmic antibody -associated vasculitis (OMAAV). The auditory disturbance improved moderately with prednisolone 40 mg/day, but multiple pulmonary masses were detected on chest computed tomography six months later. Transbronchial lung biopsy revealed granulomatosis with polyangiitis (GPA). Administration of prednisolone 50 mg/day and cyclophosphamide 500 mg once every two weeks for 12 weeks improved the lung lesions, but no further improvement in the hearing ability was observed. Prednisolone monotherapy was not able to prevent progression of OMAAV to GPA. |
| first_indexed | 2024-04-13T11:45:48Z |
| format | Article |
| id | doaj.art-45c7e01641044f5ea73387e979f8a4ab |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-13T11:45:48Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-45c7e01641044f5ea73387e979f8a4ab2022-12-22T02:48:11ZengElsevierRespiratory Medicine Case Reports2213-00712022-01-0140101771Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case reportHirokazu Tokuyasu0Saaya Hosoda1Yuriko Sueda2Hiromitsu Sakai3Natsumi Omura-Tanaka4Hiroshi Miura5Ryota Okazaki6Akira Yamasaki7Divisions of Respiratory Medicine, Matsue Red Cross Hospital, Matsue, Japan; Corresponding author. Department of Respiratory Medicine, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Matsue, 690-8506, Japan.Divisions of Respiratory Medicine, Matsue Red Cross Hospital, Matsue, JapanDivisions of Respiratory Medicine, Matsue Red Cross Hospital, Matsue, JapanDivisions of Respiratory Medicine, Matsue Red Cross Hospital, Matsue, JapanDivisions of Respiratory Medicine, Matsue Red Cross Hospital, Matsue, JapanDivisions of Pathology, Matsue Red Cross Hospital, Matsue, JapanDivision of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, Yonago, JapanA 78-year-old woman with severe auditory disturbance was referred to our hospital and was diagnosed with otitis media with anti-neutrophil cytoplasmic antibody -associated vasculitis (OMAAV). The auditory disturbance improved moderately with prednisolone 40 mg/day, but multiple pulmonary masses were detected on chest computed tomography six months later. Transbronchial lung biopsy revealed granulomatosis with polyangiitis (GPA). Administration of prednisolone 50 mg/day and cyclophosphamide 500 mg once every two weeks for 12 weeks improved the lung lesions, but no further improvement in the hearing ability was observed. Prednisolone monotherapy was not able to prevent progression of OMAAV to GPA.http://www.sciencedirect.com/science/article/pii/S2213007122001939Endobronchial ultrasonography with a guide-sheathAnti-neutrophil cytoplasmic antibodyGranulomatosis with polyangiitisNon-tuberculous mycobacteria-associated pulmonary diseaseOtitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis |
| spellingShingle | Hirokazu Tokuyasu Saaya Hosoda Yuriko Sueda Hiromitsu Sakai Natsumi Omura-Tanaka Hiroshi Miura Ryota Okazaki Akira Yamasaki Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report Respiratory Medicine Case Reports Endobronchial ultrasonography with a guide-sheath Anti-neutrophil cytoplasmic antibody Granulomatosis with polyangiitis Non-tuberculous mycobacteria-associated pulmonary disease Otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis |
| title | Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report |
| title_full | Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report |
| title_fullStr | Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report |
| title_full_unstemmed | Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report |
| title_short | Granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti-neutrophil cytoplasmic antibody-associated vasculitis: A case report |
| title_sort | granulomatosis with polyangiitis diagnosed during the treatment of otitis media with prednisolone in a patient with anti neutrophil cytoplasmic antibody associated vasculitis a case report |
| topic | Endobronchial ultrasonography with a guide-sheath Anti-neutrophil cytoplasmic antibody Granulomatosis with polyangiitis Non-tuberculous mycobacteria-associated pulmonary disease Otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis |
| url | http://www.sciencedirect.com/science/article/pii/S2213007122001939 |
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