Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy
Background/Aim: To evaluate the effectiveness of combination therapy including subantimicrobial dose doxycycline (SDD) and locally delivered doxycycline (LD) as adjuncts to scaling and root planing (SRP) in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM). Mate...
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| Format: | Article |
| Language: | English |
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Balkan Stomatological Society
2018-03-01
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| Series: | Balkan Journal of Dental Medicine |
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| Online Access: | https://doi.org/10.2478/bjdm-2018-0006 |
| _version_ | 1817969853636542464 |
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| author | Gomaa Marwa Abdelhakim Guindy Hoda Mohamed El El-Zamrany Enas Arafa |
| author_facet | Gomaa Marwa Abdelhakim Guindy Hoda Mohamed El El-Zamrany Enas Arafa |
| author_sort | Gomaa Marwa Abdelhakim |
| collection | DOAJ |
| description | Background/Aim: To evaluate the effectiveness of combination therapy including subantimicrobial dose doxycycline (SDD) and locally delivered doxycycline (LD) as adjuncts to scaling and root planing (SRP) in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM). Material and Methods: Forty patients with controlled T2DM (HbA1c ≤7%) and chronic periodontitis were selected. They were randomly divided into two groups, twenty patients each: Test group (TG, n=20) patients was treated with combination therapy of full mouth SRP, LD gel 10% and SDD 20 mg twice daily for 6 months. Control group (CG, n=20) patients was treated with full mouth SRP only. The periodontal parameters were recorded at baseline, 3, 6 and 9 months and included periodontal probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of matrix metalloproteinase-8 (MMP-8) was carried out by using Enzyme-Linked Immunosorbent Assay (ELIZA) at baseline, 3, 6 and 9 months. Results: Statistically significant reduction in all clinical parameters (PPD, CAL, and BOP) was observed at TG over CG at 3, 6, and 9 months (p<0.05). Moreover, combination therapy provided significant reductions in the amount of GCF MMP-8 for the TG compared to CG at 3, 6, and 9 months evaluation period (p<0.05). Conclusions: Combination therapy including SRP, SDD, and LD, provided significantly greater clinical benefits than SRP alone in the treatment of chronic periodontitis in patients with controlled T2DM. |
| first_indexed | 2024-04-13T20:26:29Z |
| format | Article |
| id | doaj.art-45c9a7271ce1400aa371938b17c2b16c |
| institution | Directory Open Access Journal |
| issn | 2335-0245 |
| language | English |
| last_indexed | 2024-04-13T20:26:29Z |
| publishDate | 2018-03-01 |
| publisher | Balkan Stomatological Society |
| record_format | Article |
| series | Balkan Journal of Dental Medicine |
| spelling | doaj.art-45c9a7271ce1400aa371938b17c2b16c2022-12-22T02:31:19ZengBalkan Stomatological SocietyBalkan Journal of Dental Medicine2335-02452018-03-01221323710.2478/bjdm-2018-0006bjdm-2018-0006Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination TherapyGomaa Marwa Abdelhakim0Guindy Hoda Mohamed El1El-Zamrany Enas Arafa2Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology Faculty of Dentistry, Tanta University, El Guish St., Tanta, EgyptFaculty of Dentistry, Tanta University, Tanta, EgyptFaculty of Medicine, Tanta University, Tanta, EgyptBackground/Aim: To evaluate the effectiveness of combination therapy including subantimicrobial dose doxycycline (SDD) and locally delivered doxycycline (LD) as adjuncts to scaling and root planing (SRP) in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM). Material and Methods: Forty patients with controlled T2DM (HbA1c ≤7%) and chronic periodontitis were selected. They were randomly divided into two groups, twenty patients each: Test group (TG, n=20) patients was treated with combination therapy of full mouth SRP, LD gel 10% and SDD 20 mg twice daily for 6 months. Control group (CG, n=20) patients was treated with full mouth SRP only. The periodontal parameters were recorded at baseline, 3, 6 and 9 months and included periodontal probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of matrix metalloproteinase-8 (MMP-8) was carried out by using Enzyme-Linked Immunosorbent Assay (ELIZA) at baseline, 3, 6 and 9 months. Results: Statistically significant reduction in all clinical parameters (PPD, CAL, and BOP) was observed at TG over CG at 3, 6, and 9 months (p<0.05). Moreover, combination therapy provided significant reductions in the amount of GCF MMP-8 for the TG compared to CG at 3, 6, and 9 months evaluation period (p<0.05). Conclusions: Combination therapy including SRP, SDD, and LD, provided significantly greater clinical benefits than SRP alone in the treatment of chronic periodontitis in patients with controlled T2DM.https://doi.org/10.2478/bjdm-2018-0006diabetes mellitusgingival crevicular fluidmatrix metalloproteinase-8periodontal therapysubantimicrobial dose doxycycline |
| spellingShingle | Gomaa Marwa Abdelhakim Guindy Hoda Mohamed El El-Zamrany Enas Arafa Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy Balkan Journal of Dental Medicine diabetes mellitus gingival crevicular fluid matrix metalloproteinase-8 periodontal therapy subantimicrobial dose doxycycline |
| title | Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy |
| title_full | Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy |
| title_fullStr | Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy |
| title_full_unstemmed | Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy |
| title_short | Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy |
| title_sort | adjunctive subantimicrobial dose doxycycline in the treatment of chronic periodontitis in type 2 diabetic patients a unique combination therapy |
| topic | diabetes mellitus gingival crevicular fluid matrix metalloproteinase-8 periodontal therapy subantimicrobial dose doxycycline |
| url | https://doi.org/10.2478/bjdm-2018-0006 |
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