A case report of mitotically active ovarian cellular fibroma with minor sex cord elements
Introduction: Mitotically active cellular fibroma (MACF) with Minor Sex Cord Elements is a extremely rare disease. Although imaging helps in the diagnosis to some extent, the final and definitive diagnosis is based on evaluation and histological studies. The main differential diagnosis of this tumor...
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2023-04-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_22366_0b63d2a9fd7313a5e11ca0fa2498a930.pdf |
| _version_ | 1797795236957650944 |
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| author | Amir Hossein Jafarian Morteza Safari Tirtashi Malihe Hasanzadeh Mofrad |
| author_facet | Amir Hossein Jafarian Morteza Safari Tirtashi Malihe Hasanzadeh Mofrad |
| author_sort | Amir Hossein Jafarian |
| collection | DOAJ |
| description | Introduction: Mitotically active cellular fibroma (MACF) with Minor Sex Cord Elements is a extremely rare disease. Although imaging helps in the diagnosis to some extent, the final and definitive diagnosis is based on evaluation and histological studies. The main differential diagnosis of this tumor is ovarian fibrosarcoma, which has moderate to severe atypia and a poorer prognosis. In this study, a case of mitotically active ovarian cellular fibroma with minor sex cord elements is reported.
Case presentation: A 41-year-old woman referred to gynecologic clinic with abdominal pain and abnormal uterine bleeding in the form of spotting. Clinical findings had no signs for diagnosis. Serum Tumor markers including CA125 were within normal limit. Ultrasound and computed tomography (CT) were supportive of sex cord stromal tumors. After surgical procedures and pathologic evaluation, the patient was finally diagnosed as MACF with less than 10% sex cord elements.
Conclusion: Differentiating mitotically active cellular fibroma from fibrosarcoma which may have similar histological findings is important to prevent overtreatment of patient with cellular fibroma. |
| first_indexed | 2024-03-13T03:14:53Z |
| format | Article |
| id | doaj.art-45cb2a09a6864196ae493c45ed5e6362 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-03-13T03:14:53Z |
| publishDate | 2023-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-45cb2a09a6864196ae493c45ed5e63622023-06-26T04:29:06ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632023-04-0126211912310.22038/ijogi.2023.2236622366A case report of mitotically active ovarian cellular fibroma with minor sex cord elementsAmir Hossein Jafarian0Morteza Safari Tirtashi1Malihe Hasanzadeh Mofrad2Assistant professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Resident, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Mitotically active cellular fibroma (MACF) with Minor Sex Cord Elements is a extremely rare disease. Although imaging helps in the diagnosis to some extent, the final and definitive diagnosis is based on evaluation and histological studies. The main differential diagnosis of this tumor is ovarian fibrosarcoma, which has moderate to severe atypia and a poorer prognosis. In this study, a case of mitotically active ovarian cellular fibroma with minor sex cord elements is reported. Case presentation: A 41-year-old woman referred to gynecologic clinic with abdominal pain and abnormal uterine bleeding in the form of spotting. Clinical findings had no signs for diagnosis. Serum Tumor markers including CA125 were within normal limit. Ultrasound and computed tomography (CT) were supportive of sex cord stromal tumors. After surgical procedures and pathologic evaluation, the patient was finally diagnosed as MACF with less than 10% sex cord elements. Conclusion: Differentiating mitotically active cellular fibroma from fibrosarcoma which may have similar histological findings is important to prevent overtreatment of patient with cellular fibroma.https://ijogi.mums.ac.ir/article_22366_0b63d2a9fd7313a5e11ca0fa2498a930.pdffibromafibrosarcomaovary |
| spellingShingle | Amir Hossein Jafarian Morteza Safari Tirtashi Malihe Hasanzadeh Mofrad A case report of mitotically active ovarian cellular fibroma with minor sex cord elements Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān fibroma fibrosarcoma ovary |
| title | A case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| title_full | A case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| title_fullStr | A case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| title_full_unstemmed | A case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| title_short | A case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| title_sort | case report of mitotically active ovarian cellular fibroma with minor sex cord elements |
| topic | fibroma fibrosarcoma ovary |
| url | https://ijogi.mums.ac.ir/article_22366_0b63d2a9fd7313a5e11ca0fa2498a930.pdf |
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