Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo

Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo

Abstract We investigated the anti-angiogenic and pro-apoptotic effects of robustaflavone (RF), a naturally occurring biflavonoid, on human umbilical vein endothelial cells (HUVECs). RF inhibited HUVEC proliferation and showed cytotoxicity that inhibited HUVEC viability. RF-induced apoptosis was char...

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Bibliographic Details
Main Authors: Woo Kyung Sim, Jong-Hwa Park, Ki-Young Kim, In Sik Chung
Format: Article
Language:English
Published: Nature Portfolio 2020-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-67993-5

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