Developments of microfluidics for orthopedic applications: A review
With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent co...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-01-01
|
| Series: | Smart Materials in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590183422000333 |
| _version_ | 1827895771444281344 |
|---|---|
| author | Miao Sun Jiaxing Gong Wushi Cui Congsun Li Mengfei Yu Hua Ye Zhanfeng Cui Jing Chen Yong He An Liu Huiming Wang |
| author_facet | Miao Sun Jiaxing Gong Wushi Cui Congsun Li Mengfei Yu Hua Ye Zhanfeng Cui Jing Chen Yong He An Liu Huiming Wang |
| author_sort | Miao Sun |
| collection | DOAJ |
| description | With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics. |
| first_indexed | 2024-03-12T22:26:32Z |
| format | Article |
| id | doaj.art-45cd9584338a4245bf775f62fddbe04c |
| institution | Directory Open Access Journal |
| issn | 2590-1834 |
| language | English |
| last_indexed | 2024-03-12T22:26:32Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Smart Materials in Medicine |
| spelling | doaj.art-45cd9584338a4245bf775f62fddbe04c2023-07-22T04:52:37ZengKeAi Communications Co., Ltd.Smart Materials in Medicine2590-18342023-01-014111122Developments of microfluidics for orthopedic applications: A reviewMiao Sun0Jiaxing Gong1Wushi Cui2Congsun Li3Mengfei Yu4Hua Ye5Zhanfeng Cui6Jing Chen7Yong He8An Liu9Huiming Wang10The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, ChinaThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, ChinaDepartment of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Orthopedics Research Institute of Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Orthopedics Research Institute of Zhejiang University, Hangzhou, ChinaThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, ChinaInstitute of Biomedical Engineering, Department of Engineering Science,University of Oxford, Oxford, UKInstitute of Biomedical Engineering, Department of Engineering Science,University of Oxford, Oxford, UKCixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Cixi, Ningbo, 315300, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, China; Corresponding author. State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Orthopedics Research Institute of Zhejiang University, Hangzhou, China; Corresponding author. Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, China; Corresponding author. The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China.With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics.http://www.sciencedirect.com/science/article/pii/S2590183422000333BoneMicrofluidicRegenerationOrthopedicTissue engineering |
| spellingShingle | Miao Sun Jiaxing Gong Wushi Cui Congsun Li Mengfei Yu Hua Ye Zhanfeng Cui Jing Chen Yong He An Liu Huiming Wang Developments of microfluidics for orthopedic applications: A review Smart Materials in Medicine Bone Microfluidic Regeneration Orthopedic Tissue engineering |
| title | Developments of microfluidics for orthopedic applications: A review |
| title_full | Developments of microfluidics for orthopedic applications: A review |
| title_fullStr | Developments of microfluidics for orthopedic applications: A review |
| title_full_unstemmed | Developments of microfluidics for orthopedic applications: A review |
| title_short | Developments of microfluidics for orthopedic applications: A review |
| title_sort | developments of microfluidics for orthopedic applications a review |
| topic | Bone Microfluidic Regeneration Orthopedic Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2590183422000333 |
| work_keys_str_mv | AT miaosun developmentsofmicrofluidicsfororthopedicapplicationsareview AT jiaxinggong developmentsofmicrofluidicsfororthopedicapplicationsareview AT wushicui developmentsofmicrofluidicsfororthopedicapplicationsareview AT congsunli developmentsofmicrofluidicsfororthopedicapplicationsareview AT mengfeiyu developmentsofmicrofluidicsfororthopedicapplicationsareview AT huaye developmentsofmicrofluidicsfororthopedicapplicationsareview AT zhanfengcui developmentsofmicrofluidicsfororthopedicapplicationsareview AT jingchen developmentsofmicrofluidicsfororthopedicapplicationsareview AT yonghe developmentsofmicrofluidicsfororthopedicapplicationsareview AT anliu developmentsofmicrofluidicsfororthopedicapplicationsareview AT huimingwang developmentsofmicrofluidicsfororthopedicapplicationsareview |