Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study.
Smoking-related interstitial lung abnormalities are different from specific forms of fibrosing lung disease which might be associated with poor prognoses. Chronic obstructive pulmonary disease with comorbid interstitial lung abnormalities and that with pulmonary fibrosis are considered different dis...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0239764 |
| _version_ | 1819145777503535104 |
|---|---|
| author | Manabu Ono Seiichi Kobayashi Masakazu Hanagama Masatsugu Ishida Hikari Sato Tomonori Makiguchi Masaru Yanai |
| author_facet | Manabu Ono Seiichi Kobayashi Masakazu Hanagama Masatsugu Ishida Hikari Sato Tomonori Makiguchi Masaru Yanai |
| author_sort | Manabu Ono |
| collection | DOAJ |
| description | Smoking-related interstitial lung abnormalities are different from specific forms of fibrosing lung disease which might be associated with poor prognoses. Chronic obstructive pulmonary disease with comorbid interstitial lung abnormalities and that with pulmonary fibrosis are considered different diseases; however, they could share a common spectrum. We aimed to evaluate the clinical characteristics of Japanese patients with chronic obstructive pulmonary disease and comorbid interstitial lung abnormalities. In this prospective observational study, we analyzed data from the Ishinomaki COPD Network Registry. We evaluated the clinical characteristics of patients with chronic obstructive pulmonary disease with and without comorbid interstitial lung abnormalities by comparing the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period. Among 463 patients with chronic obstructive pulmonary disease, 30 (6.5%) developed new interstitial lung abnormalities during the observational period. After 1-to-3 propensity score matching, we found that the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period was 0.06 and 0.23 per year in the interstitial lung abnormality and control groups, respectively (P = 0.043). Our findings indicate slow progression of interstitial lung abnormality lesions in patients with pre-existing chronic obstructive pulmonary disease. Further, interstitial lung abnormality development did not significantly influence on chronic obstructive pulmonary disease exacerbation. We speculate that post-chronic obstructive pulmonary disease interstitial lung abnormalities might involve smoking-related interstitial fibrosis, which is different from specific forms of fibrosing lung disease associated with poor prognoses. |
| first_indexed | 2024-12-22T13:03:25Z |
| format | Article |
| id | doaj.art-45cec63749e3440abc3fc26ed856872e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T13:03:25Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-45cec63749e3440abc3fc26ed856872e2022-12-21T18:24:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011511e023976410.1371/journal.pone.0239764Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study.Manabu OnoSeiichi KobayashiMasakazu HanagamaMasatsugu IshidaHikari SatoTomonori MakiguchiMasaru YanaiSmoking-related interstitial lung abnormalities are different from specific forms of fibrosing lung disease which might be associated with poor prognoses. Chronic obstructive pulmonary disease with comorbid interstitial lung abnormalities and that with pulmonary fibrosis are considered different diseases; however, they could share a common spectrum. We aimed to evaluate the clinical characteristics of Japanese patients with chronic obstructive pulmonary disease and comorbid interstitial lung abnormalities. In this prospective observational study, we analyzed data from the Ishinomaki COPD Network Registry. We evaluated the clinical characteristics of patients with chronic obstructive pulmonary disease with and without comorbid interstitial lung abnormalities by comparing the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period. Among 463 patients with chronic obstructive pulmonary disease, 30 (6.5%) developed new interstitial lung abnormalities during the observational period. After 1-to-3 propensity score matching, we found that the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period was 0.06 and 0.23 per year in the interstitial lung abnormality and control groups, respectively (P = 0.043). Our findings indicate slow progression of interstitial lung abnormality lesions in patients with pre-existing chronic obstructive pulmonary disease. Further, interstitial lung abnormality development did not significantly influence on chronic obstructive pulmonary disease exacerbation. We speculate that post-chronic obstructive pulmonary disease interstitial lung abnormalities might involve smoking-related interstitial fibrosis, which is different from specific forms of fibrosing lung disease associated with poor prognoses.https://doi.org/10.1371/journal.pone.0239764 |
| spellingShingle | Manabu Ono Seiichi Kobayashi Masakazu Hanagama Masatsugu Ishida Hikari Sato Tomonori Makiguchi Masaru Yanai Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. PLoS ONE |
| title | Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. |
| title_full | Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. |
| title_fullStr | Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. |
| title_full_unstemmed | Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. |
| title_short | Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study. |
| title_sort | clinical characteristics of japanese patients with chronic obstructive pulmonary disease copd with comorbid interstitial lung abnormalities a cross sectional study |
| url | https://doi.org/10.1371/journal.pone.0239764 |
| work_keys_str_mv | AT manabuono clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT seiichikobayashi clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT masakazuhanagama clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT masatsuguishida clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT hikarisato clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT tomonorimakiguchi clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy AT masaruyanai clinicalcharacteristicsofjapanesepatientswithchronicobstructivepulmonarydiseasecopdwithcomorbidinterstitiallungabnormalitiesacrosssectionalstudy |