Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos
Curcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga, Faculty of Veterinary Medicine
2024-04-01
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| Series: | Jurnal Medik Veteriner |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/50071 |
| _version_ | 1797232517394202624 |
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| author | Gustini Syahbirin Kurnia Alysia Aditianingrum Kusdiantoro Mohamad |
| author_facet | Gustini Syahbirin Kurnia Alysia Aditianingrum Kusdiantoro Mohamad |
| author_sort | Gustini Syahbirin |
| collection | DOAJ |
| description | Curcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the potential active compounds contained in the extract. The crude ethanol extract showed a 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 224 ppm against zebrafish embryos. Based on the gas chromatography-mass spectrometry analysis, the suspected active compounds that play a role in the toxicity were epicurzerenone, curzerene, and curzerenone, while 2,4,6-trimethylacetophenone was the predominant compound. |
| first_indexed | 2024-04-24T16:01:32Z |
| format | Article |
| id | doaj.art-45cef768dca84c608006793da2b25926 |
| institution | Directory Open Access Journal |
| issn | 2615-7497 2581-012X |
| language | English |
| last_indexed | 2024-04-24T16:01:32Z |
| publishDate | 2024-04-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj.art-45cef768dca84c608006793da2b259262024-04-01T07:00:11ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2024-04-017171810.20473/jmv.vol7.iss1.2024.7-1848218Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish EmbryosGustini Syahbirin0Kurnia Alysia Aditianingrum1Kusdiantoro Mohamad2https://orcid.org/0000-0002-7143-168XDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, IndonesiaUndergraduate Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, IndonesiaDivision of Anatomy Histology and Embryology, School of Veterinary Medicine and Biomedical Sciences, IPB University, IndonesiaCurcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the potential active compounds contained in the extract. The crude ethanol extract showed a 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 224 ppm against zebrafish embryos. Based on the gas chromatography-mass spectrometry analysis, the suspected active compounds that play a role in the toxicity were epicurzerenone, curzerene, and curzerenone, while 2,4,6-trimethylacetophenone was the predominant compound.https://e-journal.unair.ac.id/JMV/article/view/50071acute toxicityartemia salinacurcuma zedoariadanio reriolc50 |
| spellingShingle | Gustini Syahbirin Kurnia Alysia Aditianingrum Kusdiantoro Mohamad Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos Jurnal Medik Veteriner acute toxicity artemia salina curcuma zedoaria danio rerio lc50 |
| title | Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos |
| title_full | Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos |
| title_fullStr | Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos |
| title_full_unstemmed | Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos |
| title_short | Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos |
| title_sort | acute toxicity of ethanol extract of curcuma zedoaria rosc zingiberaceae rhizomes on brine shrimp larvae and zebrafish embryos |
| topic | acute toxicity artemia salina curcuma zedoaria danio rerio lc50 |
| url | https://e-journal.unair.ac.id/JMV/article/view/50071 |
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