How I manage frontline transplant-ineligible multiple myeloma
The Multiple Myeloma (MM) is a plasma cells hematological malignancy with a median age of 69 years at diagnosis. The autologous stem cell transplantation is the standard of care for this disease but less than half of newly diagnosed patients are assessed for this treatment due to comorbidities or co...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/8956 |
| _version_ | 1797936671955615744 |
|---|---|
| author | Daniele Derudas Francesca Capraro Giovanni Martinelli Claudio Cerchione |
| author_facet | Daniele Derudas Francesca Capraro Giovanni Martinelli Claudio Cerchione |
| author_sort | Daniele Derudas |
| collection | DOAJ |
| description | The Multiple Myeloma (MM) is a plasma cells hematological malignancy with a median age of 69 years at diagnosis. The autologous stem cell transplantation is the standard of care for this disease but less than half of newly diagnosed patients are assessed for this treatment due to comorbidities or complications of disease. The management of transplant ineligible MM patients is based on the balance safety and efficacy of the new available regimen and a careful assessment of the frailty status is mandatory to define the goals. In this review we discuss of the clinical dilemmas in the management and define how to manage them based on the evidence from clinical trials and “real life” experience. |
| first_indexed | 2024-04-10T18:34:02Z |
| format | Article |
| id | doaj.art-45d0807573a942afa5e04cb68456b69a |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:34:02Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-45d0807573a942afa5e04cb68456b69a2023-02-02T02:23:57ZengMDPI AGHematology Reports2038-83222038-83302020-09-0112s110.4081/hr.2020.8956How I manage frontline transplant-ineligible multiple myelomaDaniele Derudas0Francesca Capraro1Giovanni Martinelli2Claudio Cerchione3S.C. di Ematologia e C.T.M.O. – Ospedale Oncologico di Riferimento Regionale “A. Businco”, Cagliari (CA)S.C. di Ematologia e C.T.M.O. – Ospedale Oncologico di Riferimento Regionale “A. Businco”, Cagliari (CA)Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC)Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC)The Multiple Myeloma (MM) is a plasma cells hematological malignancy with a median age of 69 years at diagnosis. The autologous stem cell transplantation is the standard of care for this disease but less than half of newly diagnosed patients are assessed for this treatment due to comorbidities or complications of disease. The management of transplant ineligible MM patients is based on the balance safety and efficacy of the new available regimen and a careful assessment of the frailty status is mandatory to define the goals. In this review we discuss of the clinical dilemmas in the management and define how to manage them based on the evidence from clinical trials and “real life” experience.https://www.pagepress.org/journals/index.php/hr/article/view/8956Multiple Myelomatransplant-ineligible |
| spellingShingle | Daniele Derudas Francesca Capraro Giovanni Martinelli Claudio Cerchione How I manage frontline transplant-ineligible multiple myeloma Hematology Reports Multiple Myeloma transplant-ineligible |
| title | How I manage frontline transplant-ineligible multiple myeloma |
| title_full | How I manage frontline transplant-ineligible multiple myeloma |
| title_fullStr | How I manage frontline transplant-ineligible multiple myeloma |
| title_full_unstemmed | How I manage frontline transplant-ineligible multiple myeloma |
| title_short | How I manage frontline transplant-ineligible multiple myeloma |
| title_sort | how i manage frontline transplant ineligible multiple myeloma |
| topic | Multiple Myeloma transplant-ineligible |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/8956 |
| work_keys_str_mv | AT danielederudas howimanagefrontlinetransplantineligiblemultiplemyeloma AT francescacapraro howimanagefrontlinetransplantineligiblemultiplemyeloma AT giovannimartinelli howimanagefrontlinetransplantineligiblemultiplemyeloma AT claudiocerchione howimanagefrontlinetransplantineligiblemultiplemyeloma |