Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population
Abstract Background Triglyceride glucose-body mass index (TyG-BMI) is a recently developed alternative indicator to identify insulin resistance. However, few studies have investigated the association between the TyG-BMI and nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to stu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-021-01506-9 |
| _version_ | 1818653229670465536 |
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| author | Rongsheng Wang Longlong DAI Yanjia Zhong Guobo Xie |
| author_facet | Rongsheng Wang Longlong DAI Yanjia Zhong Guobo Xie |
| author_sort | Rongsheng Wang |
| collection | DOAJ |
| description | Abstract Background Triglyceride glucose-body mass index (TyG-BMI) is a recently developed alternative indicator to identify insulin resistance. However, few studies have investigated the association between the TyG-BMI and nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to study the relationship between NAFLD and the TyG-BMI in the general population and its predictive value. Methods A cross-sectional study was conducted on 14,251 general subjects who took part in a comprehensive health examination. The anthropological characteristics and many risk factors for NAFLD were measured. Results After fully adjusting for confounding variables, a stable positive correlation was found between NAFLD and the TyG-BMI (OR: 3.90 per SD increase; 95% CI: 3.54 to 4.29; P-trend< 0.00001). This positive correlation was not simply linear but a stable non-linear correlation. Additionally, obvious threshold effects and saturation effects were found, in which a threshold effect occurred when the TyG-BMI was between 100 and 150; when the TyG-BMI was between 300 and 400, the corresponding NAFLD risk appeared saturated. Furthermore, receiver operating characteristic analysis showed that the TyG-BMI could better predict the risk of NAFLD than other traditional indicators [TyG-BMI (AUC): 0.886; 95% CI: 0.8797–0.8927; P < 0.0001], particularly among young and middle-aged and non-obese people. Conclusions This epidemiological study is the first on the association between the TyG-BMI and NAFLD risk in the general population. In this large data set from the general population, the TyG-BMI showed an independent positive correlation with NAFLD. The discovery of the threshold effect and saturation effect between them provides a new idea to prevent and treat NAFLD. |
| first_indexed | 2024-12-17T02:34:35Z |
| format | Article |
| id | doaj.art-45d21ed8e66e42a7bb9cd9c6dbb4eb7b |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-17T02:34:35Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-45d21ed8e66e42a7bb9cd9c6dbb4eb7b2022-12-21T22:06:53ZengBMCLipids in Health and Disease1476-511X2021-07-0120111110.1186/s12944-021-01506-9Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general populationRongsheng Wang0Longlong DAI1Yanjia Zhong2Guobo Xie3Department of Intensive Care Unit, Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityDepartment of Cardiology, Ruichang People’s HospitalDepartment of Endocrinology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityDepartment of Cardiology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityAbstract Background Triglyceride glucose-body mass index (TyG-BMI) is a recently developed alternative indicator to identify insulin resistance. However, few studies have investigated the association between the TyG-BMI and nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to study the relationship between NAFLD and the TyG-BMI in the general population and its predictive value. Methods A cross-sectional study was conducted on 14,251 general subjects who took part in a comprehensive health examination. The anthropological characteristics and many risk factors for NAFLD were measured. Results After fully adjusting for confounding variables, a stable positive correlation was found between NAFLD and the TyG-BMI (OR: 3.90 per SD increase; 95% CI: 3.54 to 4.29; P-trend< 0.00001). This positive correlation was not simply linear but a stable non-linear correlation. Additionally, obvious threshold effects and saturation effects were found, in which a threshold effect occurred when the TyG-BMI was between 100 and 150; when the TyG-BMI was between 300 and 400, the corresponding NAFLD risk appeared saturated. Furthermore, receiver operating characteristic analysis showed that the TyG-BMI could better predict the risk of NAFLD than other traditional indicators [TyG-BMI (AUC): 0.886; 95% CI: 0.8797–0.8927; P < 0.0001], particularly among young and middle-aged and non-obese people. Conclusions This epidemiological study is the first on the association between the TyG-BMI and NAFLD risk in the general population. In this large data set from the general population, the TyG-BMI showed an independent positive correlation with NAFLD. The discovery of the threshold effect and saturation effect between them provides a new idea to prevent and treat NAFLD.https://doi.org/10.1186/s12944-021-01506-9TriglycerideBody mass indexTriglycerideTriglyceride glucose-body mass indexTriglyceride-glucose index |
| spellingShingle | Rongsheng Wang Longlong DAI Yanjia Zhong Guobo Xie Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population Lipids in Health and Disease Triglyceride Body mass index Triglyceride Triglyceride glucose-body mass index Triglyceride-glucose index |
| title | Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population |
| title_full | Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population |
| title_fullStr | Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population |
| title_full_unstemmed | Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population |
| title_short | Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population |
| title_sort | usefulness of the triglyceride glucose body mass index in evaluating nonalcoholic fatty liver disease insights from a general population |
| topic | Triglyceride Body mass index Triglyceride Triglyceride glucose-body mass index Triglyceride-glucose index |
| url | https://doi.org/10.1186/s12944-021-01506-9 |
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