Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors

Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors

A series of azastilbene derivatives, characterized by the presence of the 1,2,4-oxadiazole-5-one system as a linker of the two aromatic rings of stilbenes, have been prepared as novel potential inhibitors of p38 MAPK. Biological assays indicated that some of the synthesized compounds are endowed wit...

Full description

Bibliographic Details
Main Authors: Roberto Romeo, Salvatore V. Giofrè, Maria A. Chiacchio, Lucia Veltri, Consuelo Celesti, Daniela Iannazzo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
stilbene analogs
1,2,4-oxazolidinyl-5-ones
p38 MAPK inhibitors
Online Access:https://www.mdpi.com/1420-3049/26/6/1745

Similar Items

Similar Items