Clinical and laboratory manifestations of childhood and adult-onset systemic lupus erythematosus in Cipto Mangunkusumo Hospital
Background Childhood-onset SLE is more severe than the adult type. Objective To compare the clinical and laboratory manifestations of childhood- and adult-onset systemic lupus erythematosus (SLE). Methods A retrospective study on child and adult SLE patients was conducted in the Division of Pediatri...
| Hoofdauteurs: | , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Indonesian Pediatric Society Publishing House
2016-10-01
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| Reeks: | Paediatrica Indonesiana |
| Onderwerpen: | |
| Online toegang: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/692 |
| Samenvatting: | Background Childhood-onset SLE is more severe than the adult type.
Objective To compare the clinical and laboratory manifestations
of childhood- and adult-onset systemic lupus erythematosus (SLE).
Methods A retrospective study on child and adult SLE patients
was conducted in the Division of Pediatric Allergy and Immunol-
ogy, Department of Child Health and Department of Internal Medi-
cine, Medical School, University of Indonesia/CiptoMangunkusumo
Hospital (FKUI/RSCM) Jakarta.
Subjects One hundred and twenty-nine subjects met the study
criteria consisting on 54 childhood- onset (41.9%), 75 adult-onset
(58.1%), and 122 (94.6%) females and 7 (5.4%) males from Janu-
ary 1995 until December 2000.
Results Fever, arthralgia and vasculitis were the most frequent
signs found in both childhood-onset and adult-onset SLE. The liver,
spleen, lymph nodes, cardiovascular, gastrointestinal tract, and
eyes were the organs involved and significantly had a larger pro-
portion in the childhood-onset. Decrease of C3 was more frequently
found in the childhood-onset. Out of 17 childhood-onset patients
who died, 13 died at the age of 0-11 year-old. Two of the adult-
onset patients also died.
Conclusion Childhood-onset SLE had some different character-
istics compared to adult form |
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| ISSN: | 0030-9311 2338-476X |