| Summary: | <b>Objective</b> To investigate the correlation between serum anti-Müllerian hormone(AMH) and insulin-like growth factor-1(IGF-1) and polycystic ovary syndrome(PCOS). <b>Methods</b> A total of 58 PCOS patients aged 20-32 years who visited Affiliated Renhe Hospital of Three Gorges University from January 2017 to January 2018 were selected as the PCOS group, and 60 age-matched healthy people were selected as the control group. The PCOS group was divided into non-obese PCOS group （<i>n</i>=33） and obese PCOS group （<i>n</i>=25） ; The healthy control group was divided into non-obese control group (<i>n</i>=32) and obese control group (<i>n</i>=28). Serum AMH, IGF-1, total testosterone (T), luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), fasting insulin (FINS), fasting blood glucose (FBG) and other related indicators were measured in PCOS group and compared with the control group. <b>Results</b> BMI, homeostasis model assessment of insulin resistance(HOMA-IR) and FINS in obese PCOS group and obese control group were significantly higher than those in corresponding non-obese groups(<i>P</i>＜0.05). HOMA-IR, FINS, T, LH, LH/FSH, AMH and IGF-1 in obese PCOS group and no-obese PCOS group were significantly higher than those in corresponding control group(<i>P</i>＜0.05). AMH was positively correlated with E2, T, LH, LH/FSH and HOMA-IR（<i>P</i><0.05）, and IGF-1 was positively correlated with FINS and HOMA-IR（<i>P</i><0.05）, respectively. <b>Conclusion</b> Serum AMH and IGF-1 levels increase in PCOS patients， and AMH is positively correlated with E2, T, LH, LH/FSH and HOMA-IR, IGF-1 is positively correlated with FINS and HOMA-IR, suggesting their roles in the pathogenesis of PCOS.
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