Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019
Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease s...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1152 |
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| author | Aung Min Soe Mya Myat Ngwe Tun Takeshi Nabeshima Theingi Win Myat Moh Moh Htun Htin Lin Nang Sarm Hom Shingo Inoue Khine Mya Nwe Lynn Pa Pa Aye Mizuki Fukuta Kyaw Zin Thant Futoshi Hasebe Kouichi Morita Sujan Shresta Hlaing Myat Thu Meng Ling Moi |
| author_facet | Aung Min Soe Mya Myat Ngwe Tun Takeshi Nabeshima Theingi Win Myat Moh Moh Htun Htin Lin Nang Sarm Hom Shingo Inoue Khine Mya Nwe Lynn Pa Pa Aye Mizuki Fukuta Kyaw Zin Thant Futoshi Hasebe Kouichi Morita Sujan Shresta Hlaing Myat Thu Meng Ling Moi |
| author_sort | Aung Min Soe |
| collection | DOAJ |
| description | Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1–4 demonstrated that most DENV-1–4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions. |
| first_indexed | 2024-03-10T10:21:19Z |
| format | Article |
| id | doaj.art-45d5c44a5dc84a019205c3c5668f4369 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:21:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-45d5c44a5dc84a019205c3c5668f43692023-11-22T00:23:14ZengMDPI AGViruses1999-49152021-06-01136115210.3390/v13061152Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019Aung Min Soe0Mya Myat Ngwe Tun1Takeshi Nabeshima2Theingi Win Myat3Moh Moh Htun4Htin Lin5Nang Sarm Hom6Shingo Inoue7Khine Mya Nwe8Lynn Pa Pa Aye9Mizuki Fukuta10Kyaw Zin Thant11Futoshi Hasebe12Kouichi Morita13Sujan Shresta14Hlaing Myat Thu15Meng Ling Moi16Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Medical Research, Yangon 11191, MyanmarDepartment of Medical Research, Yangon 11191, MyanmarDepartment of Medical Research, Yangon 11191, MyanmarDepartment of Medical Research, Yangon 11191, MyanmarDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Medical Research, Yangon 11191, MyanmarDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Medical Research, Yangon 11191, MyanmarGraduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanLa Jolla Institute for Immunology, La Jolla, CA 92037, USADepartment of Medical Research, Yangon 11191, MyanmarDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1–4 demonstrated that most DENV-1–4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.https://www.mdpi.com/1999-4915/13/6/1152dengue outbreakMyanmarco-circulationserotypesgenotype-1DENV-3 |
| spellingShingle | Aung Min Soe Mya Myat Ngwe Tun Takeshi Nabeshima Theingi Win Myat Moh Moh Htun Htin Lin Nang Sarm Hom Shingo Inoue Khine Mya Nwe Lynn Pa Pa Aye Mizuki Fukuta Kyaw Zin Thant Futoshi Hasebe Kouichi Morita Sujan Shresta Hlaing Myat Thu Meng Ling Moi Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 Viruses dengue outbreak Myanmar co-circulation serotypes genotype-1 DENV-3 |
| title | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
| title_full | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
| title_fullStr | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
| title_full_unstemmed | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
| title_short | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
| title_sort | emergence of a novel dengue virus 3 denv 3 genotype i coincident with increased denv 3 cases in yangon myanmar between 2017 and 2019 |
| topic | dengue outbreak Myanmar co-circulation serotypes genotype-1 DENV-3 |
| url | https://www.mdpi.com/1999-4915/13/6/1152 |
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