The Cation Channel TMEM63B Is an Osmosensor Required for Hearing

The Cation Channel TMEM63B Is an Osmosensor Required for Hearing

Summary: Hypotonic stress causes the activation of swelling-activated nonselective cation channels (NSCCs), which leads to Ca2+-dependent regulatory volume decrease (RVD) and adaptive maintenance of the cell volume; however, the molecular identities of the osmosensitive NSCCs remain unclear. Here, w...

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Bibliographic Details
Main Authors: Han Du, Chang Ye, Dan Wu, Yan-Yu Zang, Linqing Zhang, Chen Chen, Xue-Yan He, Jian-Jun Yang, Ping Hu, Zhengfeng Xu, Guoqiang Wan, Yun Stone Shi
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
osmosensor
TMEM63B
TMEM63A
TMEM63C
OSCA1
hair cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305453

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