Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)?
This study aims to compare the role of both subtraction MRI and Diffusion weighted images in assessment of HCC after trans-arterial chemo embolization (TACE). Patients and methods: 32 patients having 54 HCC lesions underwent TACE. Ages ranged between 59 and 73 years (mean age 59.6); there were 26 ma...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16301231 |
| _version_ | 1811285353398534144 |
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| author | Noha Abd ElShafy ElSaid Randa Osama Kaddah Marwa Shaker Abdel Fattah Nada Mohsen Salama |
| author_facet | Noha Abd ElShafy ElSaid Randa Osama Kaddah Marwa Shaker Abdel Fattah Nada Mohsen Salama |
| author_sort | Noha Abd ElShafy ElSaid |
| collection | DOAJ |
| description | This study aims to compare the role of both subtraction MRI and Diffusion weighted images in assessment of HCC after trans-arterial chemo embolization (TACE). Patients and methods: 32 patients having 54 HCC lesions underwent TACE. Ages ranged between 59 and 73 years (mean age 59.6); there were 26 males and 6 females. All examinations were performed using Philips 1.5 T MRI (Achieva). Pre contrast: T1, T2W and In phase and out phase gradient echo sequence, dynamic: eTHRIVE technique performed. Subtraction of an unenhanced T1-weighted was from the identical post enhancement sequences in early angiographic and late arterial phases. Diffusion imaging: it was performed using single-shot spin-echo echo-planar imaging with b = 0, 300, 600 mm/s2. DWI was used to create ADC maps. Two readers blinded to each other assessed subtraction of dynamic study and DWI technique to evaluate post treatment response. Results: Reader 1 subtraction dynamic MRI sensitivity = 97%, specificity = 100% PPV = 100% and NPV = 95% compared to 70.59%, 75%, 82.76% and 60% respectively in DWI. Reader 2 subtraction dynamic MRI sensitivity = 97%, specificity = 100% PPV = 100% and NPV = 95% compared to 76.5%, 90%, 92.8% and 69% respectively in DWI. Conclusion: DW-MRI had lower accuracy measures compared to subtraction MRI with increased false negative. DWI may act as a supplementary sequence to compensate for the dynamic MRI in patients who couldn't hold their breath adequately. |
| first_indexed | 2024-04-13T02:43:55Z |
| format | Article |
| id | doaj.art-45d7991502fe44798183c5eb8ddeb1f2 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-04-13T02:43:55Z |
| publishDate | 2016-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-45d7991502fe44798183c5eb8ddeb1f22022-12-22T03:06:07ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-12-014741251126410.1016/j.ejrnm.2016.07.018Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)?Noha Abd ElShafy ElSaid0Randa Osama Kaddah1Marwa Shaker Abdel Fattah2Nada Mohsen Salama3National Cancer Institute, Cairo University, EgyptKasr ElAini, Cairo University, EgyptKasr ElAini, Cairo University, EgyptNational Cancer Institute, Cairo University, EgyptThis study aims to compare the role of both subtraction MRI and Diffusion weighted images in assessment of HCC after trans-arterial chemo embolization (TACE). Patients and methods: 32 patients having 54 HCC lesions underwent TACE. Ages ranged between 59 and 73 years (mean age 59.6); there were 26 males and 6 females. All examinations were performed using Philips 1.5 T MRI (Achieva). Pre contrast: T1, T2W and In phase and out phase gradient echo sequence, dynamic: eTHRIVE technique performed. Subtraction of an unenhanced T1-weighted was from the identical post enhancement sequences in early angiographic and late arterial phases. Diffusion imaging: it was performed using single-shot spin-echo echo-planar imaging with b = 0, 300, 600 mm/s2. DWI was used to create ADC maps. Two readers blinded to each other assessed subtraction of dynamic study and DWI technique to evaluate post treatment response. Results: Reader 1 subtraction dynamic MRI sensitivity = 97%, specificity = 100% PPV = 100% and NPV = 95% compared to 70.59%, 75%, 82.76% and 60% respectively in DWI. Reader 2 subtraction dynamic MRI sensitivity = 97%, specificity = 100% PPV = 100% and NPV = 95% compared to 76.5%, 90%, 92.8% and 69% respectively in DWI. Conclusion: DW-MRI had lower accuracy measures compared to subtraction MRI with increased false negative. DWI may act as a supplementary sequence to compensate for the dynamic MRI in patients who couldn't hold their breath adequately.http://www.sciencedirect.com/science/article/pii/S0378603X16301231Subtraction MRIDWIPost TACE HCC |
| spellingShingle | Noha Abd ElShafy ElSaid Randa Osama Kaddah Marwa Shaker Abdel Fattah Nada Mohsen Salama Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? The Egyptian Journal of Radiology and Nuclear Medicine Subtraction MRI DWI Post TACE HCC |
| title | Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? |
| title_full | Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? |
| title_fullStr | Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? |
| title_full_unstemmed | Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? |
| title_short | Subtraction MRI versus diffusion weighted imaging: Which is more accurate in assessment of hepatocellular carcinoma after Trans Arterial Chemoembolization (TACE)? |
| title_sort | subtraction mri versus diffusion weighted imaging which is more accurate in assessment of hepatocellular carcinoma after trans arterial chemoembolization tace |
| topic | Subtraction MRI DWI Post TACE HCC |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16301231 |
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