State transitions across the Strep A disease spectrum: scoping review and evidence gaps
Abstract The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spect...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08888-4 |
| _version_ | 1797350121189408768 |
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| author | Prerana Parajulee Jung-Seok Lee Kaja Abbas Jeffrey Cannon Jean Louis Excler Jerome H. Kim Vittal Mogasale |
| author_facet | Prerana Parajulee Jung-Seok Lee Kaja Abbas Jeffrey Cannon Jean Louis Excler Jerome H. Kim Vittal Mogasale |
| author_sort | Prerana Parajulee |
| collection | DOAJ |
| description | Abstract The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions. Among the included articles, the transition from an invasive or toxin-mediated disease state to another disease state (i.e., to recurrent ARF, RHD or death) was described 115 times (43.9% of all included transition pairs) while the transition to and from locally invasive category was the lowest (n = 7; 0.02%). Transitions from well to any other state was most frequently reported (49%) whereas a relatively higher number of studies (n = 71) reported transition from invasive disease to death. Transitions from any disease state to locally invasive, Strep A pharyngitis to invasive disease, and chronic kidney disease to death were lacking. Transitions related to severe invasive diseases were more frequently reported than superficial ones. Most evidence originated from high-income countries and there is a critical need for new studies in low- and middle-income countries to infer the state transitions across the Strep A disease spectrum in these high-burden settings. |
| first_indexed | 2024-03-08T12:40:15Z |
| format | Article |
| id | doaj.art-45d7d2d162ff4b429d0523a2ced3c5ca |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T12:40:15Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-45d7d2d162ff4b429d0523a2ced3c5ca2024-01-21T12:12:00ZengBMCBMC Infectious Diseases1471-23342024-01-0124111110.1186/s12879-023-08888-4State transitions across the Strep A disease spectrum: scoping review and evidence gapsPrerana Parajulee0Jung-Seok Lee1Kaja Abbas2Jeffrey Cannon3Jean Louis Excler4Jerome H. Kim5Vittal Mogasale6International Vaccine InstituteInternational Vaccine InstituteLondon School of Hygiene and Tropical MedicineTelethon Kids Institute, University of Western AustraliaInternational Vaccine InstituteInternational Vaccine InstituteInternational Vaccine InstituteAbstract The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions. Among the included articles, the transition from an invasive or toxin-mediated disease state to another disease state (i.e., to recurrent ARF, RHD or death) was described 115 times (43.9% of all included transition pairs) while the transition to and from locally invasive category was the lowest (n = 7; 0.02%). Transitions from well to any other state was most frequently reported (49%) whereas a relatively higher number of studies (n = 71) reported transition from invasive disease to death. Transitions from any disease state to locally invasive, Strep A pharyngitis to invasive disease, and chronic kidney disease to death were lacking. Transitions related to severe invasive diseases were more frequently reported than superficial ones. Most evidence originated from high-income countries and there is a critical need for new studies in low- and middle-income countries to infer the state transitions across the Strep A disease spectrum in these high-burden settings.https://doi.org/10.1186/s12879-023-08888-4Group A StreptococcusStrep A diseasePharyngitisSkin infectionAcute rheumatic feverAcute poststreptococcal glomerulonephritis |
| spellingShingle | Prerana Parajulee Jung-Seok Lee Kaja Abbas Jeffrey Cannon Jean Louis Excler Jerome H. Kim Vittal Mogasale State transitions across the Strep A disease spectrum: scoping review and evidence gaps BMC Infectious Diseases Group A Streptococcus Strep A disease Pharyngitis Skin infection Acute rheumatic fever Acute poststreptococcal glomerulonephritis |
| title | State transitions across the Strep A disease spectrum: scoping review and evidence gaps |
| title_full | State transitions across the Strep A disease spectrum: scoping review and evidence gaps |
| title_fullStr | State transitions across the Strep A disease spectrum: scoping review and evidence gaps |
| title_full_unstemmed | State transitions across the Strep A disease spectrum: scoping review and evidence gaps |
| title_short | State transitions across the Strep A disease spectrum: scoping review and evidence gaps |
| title_sort | state transitions across the strep a disease spectrum scoping review and evidence gaps |
| topic | Group A Streptococcus Strep A disease Pharyngitis Skin infection Acute rheumatic fever Acute poststreptococcal glomerulonephritis |
| url | https://doi.org/10.1186/s12879-023-08888-4 |
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