Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women
Objective: To evaluate the clinical effects of estrogen-progestin therapy in postmenopausal women, with particular emphasis on climacteric symptoms and sexuality. Methods: A prospective, blind, randomized, single-center, crossover, placebo-controlled study was carried out for 12 consecutive months i...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2008-09-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.einstein.br/revista/arquivos/PDF/832-Einsteinv6n2p170-4.pdf |
| _version_ | 1818387242145546240 |
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| author | Edmund Chada Baracat Sonia Regina Lenharo Penteado Jucilene Sales da Paixão Eduardo Blanco Cardoso Vicente Renato Bagnoli Ana Lucia Cavalcanti Angela Maggio da Fonseca |
| author_facet | Edmund Chada Baracat Sonia Regina Lenharo Penteado Jucilene Sales da Paixão Eduardo Blanco Cardoso Vicente Renato Bagnoli Ana Lucia Cavalcanti Angela Maggio da Fonseca |
| author_sort | Edmund Chada Baracat |
| collection | DOAJ |
| description | Objective: To evaluate the clinical effects of estrogen-progestin therapy in postmenopausal women, with particular emphasis on climacteric symptoms and sexuality. Methods: A prospective, blind, randomized, single-center, crossover, placebo-controlled study was carried out for 12 consecutive months in 40 postmenopausal women with a mean age of 52.2 years, with no contraindication to hormone therapy and with an intact uterus. The patients were divided into two groups: during the first six-month period of the study, one group received estradiol valerate 2 mg/day for 21 days/month associated with cyproterone acetate 1 mg/day in the last ten days of therapy (Climene™); the other group received one placebo tablet/day for 21 days/month. The treatments were then reversed, and the patients were followed-up for another six-month period. In the statistical analysis, the group receiving hormone therapy was denoted Group A, and the group receiving placebo Group B, regardless of the sequence in which the patient received the drug. Menopausal symptoms and sexuality were evaluated. Crossover analysis of variance and the McNemar test were used for statistical analysis. Rresults: A significant reduction was found in hot flashes and insomnia in the patients of Group A (the group that received hormone therapy). In this group, a significant improvement was also detected regarding sexual interest, communication with partner and ability to reach orgasm during penetration. Regarding the other issues, no statistically significant differences were detected. Cconclusions: There was a significant improvement in menopausal symptoms and sexuality in the group of women that used hormone therapy. |
| first_indexed | 2024-12-14T04:06:50Z |
| format | Article |
| id | doaj.art-45d81457182c40a681e34dd1d292d338 |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-12-14T04:06:50Z |
| publishDate | 2008-09-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-45d81457182c40a681e34dd1d292d3382022-12-21T23:17:47ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082008-09-0162170174Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal womenEdmund Chada BaracatSonia Regina Lenharo PenteadoJucilene Sales da PaixãoEduardo Blanco CardosoVicente Renato BagnoliAna Lucia CavalcantiAngela Maggio da FonsecaObjective: To evaluate the clinical effects of estrogen-progestin therapy in postmenopausal women, with particular emphasis on climacteric symptoms and sexuality. Methods: A prospective, blind, randomized, single-center, crossover, placebo-controlled study was carried out for 12 consecutive months in 40 postmenopausal women with a mean age of 52.2 years, with no contraindication to hormone therapy and with an intact uterus. The patients were divided into two groups: during the first six-month period of the study, one group received estradiol valerate 2 mg/day for 21 days/month associated with cyproterone acetate 1 mg/day in the last ten days of therapy (Climene™); the other group received one placebo tablet/day for 21 days/month. The treatments were then reversed, and the patients were followed-up for another six-month period. In the statistical analysis, the group receiving hormone therapy was denoted Group A, and the group receiving placebo Group B, regardless of the sequence in which the patient received the drug. Menopausal symptoms and sexuality were evaluated. Crossover analysis of variance and the McNemar test were used for statistical analysis. Rresults: A significant reduction was found in hot flashes and insomnia in the patients of Group A (the group that received hormone therapy). In this group, a significant improvement was also detected regarding sexual interest, communication with partner and ability to reach orgasm during penetration. Regarding the other issues, no statistically significant differences were detected. Cconclusions: There was a significant improvement in menopausal symptoms and sexuality in the group of women that used hormone therapy.http://www.einstein.br/revista/arquivos/PDF/832-Einsteinv6n2p170-4.pdfHormone replacement therapyEstrogen replacement therapyMenopauseSexualityValeratesCyproterone acetate |
| spellingShingle | Edmund Chada Baracat Sonia Regina Lenharo Penteado Jucilene Sales da Paixão Eduardo Blanco Cardoso Vicente Renato Bagnoli Ana Lucia Cavalcanti Angela Maggio da Fonseca Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women Einstein (São Paulo) Hormone replacement therapy Estrogen replacement therapy Menopause Sexuality Valerates Cyproterone acetate |
| title | Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women |
| title_full | Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women |
| title_fullStr | Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women |
| title_full_unstemmed | Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women |
| title_short | Effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality-related aspects in postmenopausal women |
| title_sort | effects of estradiol valerate associated with cyproterone acetate on some clinical and sexuality related aspects in postmenopausal women |
| topic | Hormone replacement therapy Estrogen replacement therapy Menopause Sexuality Valerates Cyproterone acetate |
| url | http://www.einstein.br/revista/arquivos/PDF/832-Einsteinv6n2p170-4.pdf |
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