Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis
The WNT signaling pathway plays an important role in the physiological and pathophysiological processes of the central nervous system and the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We reviewed the literature pertinent to WNT/β–catenin signaling in ALS from cellular studies, a...
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MDPI AG
2021-04-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/4/839 |
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| author | Xin Jiang Yingjun Guan Zhenhan Zhao Fandi Meng Xuemei Wang Xueshuai Gao Jinmeng Liu Yanchun Chen Fenghua Zhou Shuanhu Zhou Xin Wang |
| author_facet | Xin Jiang Yingjun Guan Zhenhan Zhao Fandi Meng Xuemei Wang Xueshuai Gao Jinmeng Liu Yanchun Chen Fenghua Zhou Shuanhu Zhou Xin Wang |
| author_sort | Xin Jiang |
| collection | DOAJ |
| description | The WNT signaling pathway plays an important role in the physiological and pathophysiological processes of the central nervous system and the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We reviewed the literature pertinent to WNT/β–catenin signaling in ALS from cellular studies, animal models, and human clinical trials. WNT, WNT receptors, and other components of the WNT signaling pathway are expressed in both ALS patients and transgenic mice, and are involved in the pathogenesis of ALS. Studies have shown that abnormal activation of the WNT/β–catenin signaling pathway is related to neuronal degeneration and glial cell proliferation. WNT/Ca<sup>2+</sup> signaling is associated with the pro–inflammatory phenotype of microglia; data on the muscle skeletal receptor Tyr kinase receptor in superoxide dismutase–1–G93A mice indicate that gene therapy is necessary for successful treatment of ALS. The varying profiles of lipoprotein receptor–related protein 4 antibodies in different ethnic groups suggest that individual treatment and multifactorial personalized approaches may be necessary for effective ALS therapy. In conclusion, the WNT signaling pathway is important to the ALS disease process, making it a likely therapeutic target. |
| first_indexed | 2024-03-10T12:30:47Z |
| format | Article |
| id | doaj.art-45d83d780bb0450a990ad2c3b3f858c5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T12:30:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-45d83d780bb0450a990ad2c3b3f858c52023-11-21T14:40:21ZengMDPI AGCells2073-44092021-04-0110483910.3390/cells10040839Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral SclerosisXin Jiang0Yingjun Guan1Zhenhan Zhao2Fandi Meng3Xuemei Wang4Xueshuai Gao5Jinmeng Liu6Yanchun Chen7Fenghua Zhou8Shuanhu Zhou9Xin Wang10Department of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAThe WNT signaling pathway plays an important role in the physiological and pathophysiological processes of the central nervous system and the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We reviewed the literature pertinent to WNT/β–catenin signaling in ALS from cellular studies, animal models, and human clinical trials. WNT, WNT receptors, and other components of the WNT signaling pathway are expressed in both ALS patients and transgenic mice, and are involved in the pathogenesis of ALS. Studies have shown that abnormal activation of the WNT/β–catenin signaling pathway is related to neuronal degeneration and glial cell proliferation. WNT/Ca<sup>2+</sup> signaling is associated with the pro–inflammatory phenotype of microglia; data on the muscle skeletal receptor Tyr kinase receptor in superoxide dismutase–1–G93A mice indicate that gene therapy is necessary for successful treatment of ALS. The varying profiles of lipoprotein receptor–related protein 4 antibodies in different ethnic groups suggest that individual treatment and multifactorial personalized approaches may be necessary for effective ALS therapy. In conclusion, the WNT signaling pathway is important to the ALS disease process, making it a likely therapeutic target.https://www.mdpi.com/2073-4409/10/4/839amyotrophic lateral sclerosisWNT signalingmotor neuronsglial cellsneuromuscular junctions |
| spellingShingle | Xin Jiang Yingjun Guan Zhenhan Zhao Fandi Meng Xuemei Wang Xueshuai Gao Jinmeng Liu Yanchun Chen Fenghua Zhou Shuanhu Zhou Xin Wang Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis Cells amyotrophic lateral sclerosis WNT signaling motor neurons glial cells neuromuscular junctions |
| title | Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis |
| title_full | Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis |
| title_fullStr | Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis |
| title_short | Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis |
| title_sort | potential roles of the wnt signaling pathway in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis WNT signaling motor neurons glial cells neuromuscular junctions |
| url | https://www.mdpi.com/2073-4409/10/4/839 |
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