Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach
We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML).
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-09-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/raon-2017-0040 |
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| author | Kotnik Barbara Faganel Jazbec Janez Grabar Petra Bohanec Rodriguez-Antona Cristina Dolzan Vita |
| author_facet | Kotnik Barbara Faganel Jazbec Janez Grabar Petra Bohanec Rodriguez-Antona Cristina Dolzan Vita |
| author_sort | Kotnik Barbara Faganel |
| collection | DOAJ |
| description | We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML). |
| first_indexed | 2024-12-22T04:59:46Z |
| format | Article |
| id | doaj.art-45d8f75f9cc44598a34dd45aa5202e7b |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-22T04:59:46Z |
| publishDate | 2017-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-45d8f75f9cc44598a34dd45aa5202e7b2022-12-21T18:38:18ZengSciendoRadiology and Oncology1581-32072017-09-0151445546210.1515/raon-2017-0040raon-2017-0040Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approachKotnik Barbara Faganel0Jazbec Janez1Grabar Petra Bohanec2Rodriguez-Antona Cristina3Dolzan Vita4Department of Oncology and Haematology, University Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Oncology and Haematology, University Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaHereditary Endocrine Cancer Group Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, SpainPharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaWe investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML).https://doi.org/10.1515/raon-2017-0040acute lymphoblastic leukaemiagenetic polymorphismhaplotypemethotrexate |
| spellingShingle | Kotnik Barbara Faganel Jazbec Janez Grabar Petra Bohanec Rodriguez-Antona Cristina Dolzan Vita Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach Radiology and Oncology acute lymphoblastic leukaemia genetic polymorphism haplotype methotrexate |
| title | Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach |
| title_full | Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach |
| title_fullStr | Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach |
| title_full_unstemmed | Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach |
| title_short | Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach |
| title_sort | association between slc19a1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non hodgkin malignant lymphoma introducing a haplotype based approach |
| topic | acute lymphoblastic leukaemia genetic polymorphism haplotype methotrexate |
| url | https://doi.org/10.1515/raon-2017-0040 |
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