Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study
Abstract Background Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficie...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02499-0 |
| _version_ | 1811267683745792000 |
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| author | Jongbeom Shin Eun Ran Kim Hyun Joo Jang Dong Hoon Baek Dong-Hoon Yang Bo-In Lee Kwang Bum Cho Jin Woong Cho Sung-Ae Jung Su Jin Hong Bong Min Ko The Research Group for Endoscopic Submucosal Dissection in Korean Society of Gastrointestinal Endoscopy |
| author_facet | Jongbeom Shin Eun Ran Kim Hyun Joo Jang Dong Hoon Baek Dong-Hoon Yang Bo-In Lee Kwang Bum Cho Jin Woong Cho Sung-Ae Jung Su Jin Hong Bong Min Ko The Research Group for Endoscopic Submucosal Dissection in Korean Society of Gastrointestinal Endoscopy |
| author_sort | Jongbeom Shin |
| collection | DOAJ |
| description | Abstract Background Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficient. This study aimed to investigate the long-term outcomes of ECC removal by ESD, including local recurrence and metastasis. Methods This multicenter study was conducted retrospectively on 450 consecutive patients with ECC who were treated with ESD between November 2003 and December 2013. Clinical, pathological, and endoscopic data were collected to determine tumor depth, resection margin, lymphovascular invasion, and recurrence. Results The median follow-up period was 53.8 (12–138 months). The en bloc resection rate was 85.3% (384) and in intramucosal cancer being 84.1% and in superficial submucosal invasion (SM1) cancer being 89.8% (p = 0.158). The curative resection rate was 76.0% (n = 342), and there was no statistical difference between the two groups (77.3% vs. 71.4%, p = 0.231). The overall recurrence free survival rate (RFS) was 98.7% (444/450). In patients with curative resection, there was no statistically significant difference in RFS according to invasion depth (intramucosal: 99.3% vs. SM1: 97.1%, p = 0.248). Conclusions Patients with curatively resected ECC treated with ESD showed favorable long-term outcomes. Curatively resected SM1 cancer has a RFS similar to that of intramucosal cancer. |
| first_indexed | 2024-04-12T21:07:00Z |
| format | Article |
| id | doaj.art-45da499f4e454642827787d4930cf5ab |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T21:07:00Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-45da499f4e454642827787d4930cf5ab2022-12-22T03:16:40ZengBMCBMC Gastroenterology1471-230X2022-09-0122111010.1186/s12876-022-02499-0Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort studyJongbeom Shin0Eun Ran Kim1Hyun Joo Jang2Dong Hoon Baek3Dong-Hoon Yang4Bo-In Lee5Kwang Bum Cho6Jin Woong Cho7Sung-Ae Jung8Su Jin Hong9Bong Min Ko10The Research Group for Endoscopic Submucosal Dissection in Korean Society of Gastrointestinal Endoscopy11Division of Gastroenterology, Department of Internal Medicine, Inha University School of MedicineDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Gastroenterology and Hepatology, Department of Medicine, Dongtan Sacred Heart Hospital, Hallym University School of MedicineDivision of Gastoenterology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University HospitalDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDivision of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of MedicineDepartment of Internal Medicine, Presbyterian Medical CenterDepartment of Internal Medicine, College of Medicine, Ewha Womans UniversityDepartment of Internal Medicine, Digestive Disease Center and Research Institute, Soonchunhyang University School of Medicine, Soonchunhyang University Bucheon HospitalDepartment of Internal Medicine, Digestive Disease Center and Research Institute, Soonchunhyang University School of Medicine, Soonchunhyang University Bucheon HospitalKorean Society of Gastrointestinal EndoscopyAbstract Background Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficient. This study aimed to investigate the long-term outcomes of ECC removal by ESD, including local recurrence and metastasis. Methods This multicenter study was conducted retrospectively on 450 consecutive patients with ECC who were treated with ESD between November 2003 and December 2013. Clinical, pathological, and endoscopic data were collected to determine tumor depth, resection margin, lymphovascular invasion, and recurrence. Results The median follow-up period was 53.8 (12–138 months). The en bloc resection rate was 85.3% (384) and in intramucosal cancer being 84.1% and in superficial submucosal invasion (SM1) cancer being 89.8% (p = 0.158). The curative resection rate was 76.0% (n = 342), and there was no statistical difference between the two groups (77.3% vs. 71.4%, p = 0.231). The overall recurrence free survival rate (RFS) was 98.7% (444/450). In patients with curative resection, there was no statistically significant difference in RFS according to invasion depth (intramucosal: 99.3% vs. SM1: 97.1%, p = 0.248). Conclusions Patients with curatively resected ECC treated with ESD showed favorable long-term outcomes. Curatively resected SM1 cancer has a RFS similar to that of intramucosal cancer.https://doi.org/10.1186/s12876-022-02499-0Early colorectal cancerEndoscopic submucosal dissectionRecurrence free survival |
| spellingShingle | Jongbeom Shin Eun Ran Kim Hyun Joo Jang Dong Hoon Baek Dong-Hoon Yang Bo-In Lee Kwang Bum Cho Jin Woong Cho Sung-Ae Jung Su Jin Hong Bong Min Ko The Research Group for Endoscopic Submucosal Dissection in Korean Society of Gastrointestinal Endoscopy Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study BMC Gastroenterology Early colorectal cancer Endoscopic submucosal dissection Recurrence free survival |
| title | Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study |
| title_full | Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study |
| title_fullStr | Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study |
| title_full_unstemmed | Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study |
| title_short | Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study |
| title_sort | long term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion a multicenter cohort study |
| topic | Early colorectal cancer Endoscopic submucosal dissection Recurrence free survival |
| url | https://doi.org/10.1186/s12876-022-02499-0 |
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