Study on the gestational age-related histogenesis of human fetal suprarenal glands
Background: Fetal suprarenal gland consists of three zones. They are the outer definitive zone or neocortex (DZ) that forms adult Zona Glomerulosa (ZG), the centrally located fetal zone and a third transitional zone (TZ) the future adult Zona Fasciculata (ZF) which lies just between the neocortex an...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2020-09-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/29455 |
| _version_ | 1818921818168229888 |
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| author | Maruti Ram Annamraju Ravindra Kumar Boddeti Subhadra Devi Velichety Srihari Rao Battalapalli |
| author_facet | Maruti Ram Annamraju Ravindra Kumar Boddeti Subhadra Devi Velichety Srihari Rao Battalapalli |
| author_sort | Maruti Ram Annamraju |
| collection | DOAJ |
| description | Background: Fetal suprarenal gland consists of three zones. They are the outer definitive zone or neocortex (DZ) that forms adult Zona Glomerulosa (ZG), the centrally located fetal zone and a third transitional zone (TZ) the future adult Zona Fasciculata (ZF) which lies just between the neocortex and fetal zone (FZ). The inner ZF that consists of large eosinophilic cells, and the outer definitive zone (DZ) consists of small, densely packed basophilic cells. As early as in 6th week of gestational Age, pheochromoblasts derived from the neural crest migrate through the fetal cortex to form the medulla at a later stage of development. The medulla unrecognizable as a distinct structure in the suprarenal gland throughout most of the gestation, except for small clusters or nests of chromaffin cells scattered throughout the body of the cortex.
Aims and Objective: The study was designed and aimed to understand the early developmental histology of suprarenal gland.
Materials and Methods: Study conducted at the Department of Anatomy, SV Medical College, Tirupati, Andhra Pradesh, India. The study was carried out by processing representative samples of fetal suprarenal tissues of 13 weeks, 17 weeks, 24 weeks, 25 weeks and 38 weeks gestational age. While processing, we observed the standard dissection procedure and histopathological tissue processing for the human samples.
Results: Peripheral narrower and darker definitive zone or true cortex and an inner wider and lighter fetal zone was observed at 13, 17, 24 weeks with 10x objective. The demarcation between cortex and medulla could be seen clearly at 24 weeks. At 25 weeks capsule is very thick and vascular. A well-differentiated gland tissue with clear demarcation of cortex and medulla and a large central vein was observed. At 38 weeks degeneration of fetal zone with a thick-walled central vein was observed at lower magnification (10x objective)
Conclusion: Observations on prenatal microscopic structure and gestational age-related changes in suprarenal glands form the basis for understanding structural changes and a foetal database for the local population. |
| first_indexed | 2024-12-20T01:43:41Z |
| format | Article |
| id | doaj.art-45dd701964284563898a137864756a39 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-20T01:43:41Z |
| publishDate | 2020-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-45dd701964284563898a137864756a392022-12-21T19:57:50ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762020-09-011156168https://doi.org/10.3126/ajms.v11i5.29455Study on the gestational age-related histogenesis of human fetal suprarenal glandsMaruti Ram Annamraju 0Ravindra Kumar Boddeti 1Subhadra Devi Velichety 2Srihari Rao Battalapalli 3Associate Professor of Anatomy, ACSR Govt Medical college, Nellore, Andhra Pradesh, India https://orcid.org/0000-0003-2661-8792PhD Scholar, Department of Anatomy, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India https://orcid.org/0000-0003-0569-1472Professor of Anatomy, Apollo Institute of Medical Sciences and Research, Chittoor, Andhra Pradesh, India https://orcid.org/0000-0002-3995-8449Professor, Department of General Surgery, SVIMS-SPMCW, Tirupati, Andhra Pradesh, India https://orcid.org/0000-0003-0329-1352Background: Fetal suprarenal gland consists of three zones. They are the outer definitive zone or neocortex (DZ) that forms adult Zona Glomerulosa (ZG), the centrally located fetal zone and a third transitional zone (TZ) the future adult Zona Fasciculata (ZF) which lies just between the neocortex and fetal zone (FZ). The inner ZF that consists of large eosinophilic cells, and the outer definitive zone (DZ) consists of small, densely packed basophilic cells. As early as in 6th week of gestational Age, pheochromoblasts derived from the neural crest migrate through the fetal cortex to form the medulla at a later stage of development. The medulla unrecognizable as a distinct structure in the suprarenal gland throughout most of the gestation, except for small clusters or nests of chromaffin cells scattered throughout the body of the cortex. Aims and Objective: The study was designed and aimed to understand the early developmental histology of suprarenal gland. Materials and Methods: Study conducted at the Department of Anatomy, SV Medical College, Tirupati, Andhra Pradesh, India. The study was carried out by processing representative samples of fetal suprarenal tissues of 13 weeks, 17 weeks, 24 weeks, 25 weeks and 38 weeks gestational age. While processing, we observed the standard dissection procedure and histopathological tissue processing for the human samples. Results: Peripheral narrower and darker definitive zone or true cortex and an inner wider and lighter fetal zone was observed at 13, 17, 24 weeks with 10x objective. The demarcation between cortex and medulla could be seen clearly at 24 weeks. At 25 weeks capsule is very thick and vascular. A well-differentiated gland tissue with clear demarcation of cortex and medulla and a large central vein was observed. At 38 weeks degeneration of fetal zone with a thick-walled central vein was observed at lower magnification (10x objective) Conclusion: Observations on prenatal microscopic structure and gestational age-related changes in suprarenal glands form the basis for understanding structural changes and a foetal database for the local population.https://www.nepjol.info/index.php/AJMS/article/view/29455suprarenal gland (sg)definitive zone (dz)fetal zone (fz) |
| spellingShingle | Maruti Ram Annamraju Ravindra Kumar Boddeti Subhadra Devi Velichety Srihari Rao Battalapalli Study on the gestational age-related histogenesis of human fetal suprarenal glands Asian Journal of Medical Sciences suprarenal gland (sg) definitive zone (dz) fetal zone (fz) |
| title | Study on the gestational age-related histogenesis of human fetal suprarenal glands |
| title_full | Study on the gestational age-related histogenesis of human fetal suprarenal glands |
| title_fullStr | Study on the gestational age-related histogenesis of human fetal suprarenal glands |
| title_full_unstemmed | Study on the gestational age-related histogenesis of human fetal suprarenal glands |
| title_short | Study on the gestational age-related histogenesis of human fetal suprarenal glands |
| title_sort | study on the gestational age related histogenesis of human fetal suprarenal glands |
| topic | suprarenal gland (sg) definitive zone (dz) fetal zone (fz) |
| url | https://www.nepjol.info/index.php/AJMS/article/view/29455 |
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