Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Although significant progress has been made in recent years to treat DLBCL patients, 30%–40% of the patients eventually relapse or are refractory to first line treatment, calling for better therapeutic strategies...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/7/1/1 |
| _version_ | 1798000642127560704 |
|---|---|
| author | Kasper Thystrup Karstensen Aleks Schein Andreas Petri Martin Bøgsted Karen Dybkær Shizuka Uchida Sakari Kauppinen |
| author_facet | Kasper Thystrup Karstensen Aleks Schein Andreas Petri Martin Bøgsted Karen Dybkær Shizuka Uchida Sakari Kauppinen |
| author_sort | Kasper Thystrup Karstensen |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Although significant progress has been made in recent years to treat DLBCL patients, 30%–40% of the patients eventually relapse or are refractory to first line treatment, calling for better therapeutic strategies for DLBCL. Long non-coding RNAs (lncRNAs) have emerged as a highly diverse group of non-protein coding transcripts with intriguing molecular functions in human disease, including cancer. Here, we review the current understanding of lncRNAs in the pathogenesis and progression of DLBCL to provide an overview of the field. As the current knowledge of lncRNAs in DLBCL is still in its infancy, we provide molecular signatures of lncRNAs in DLBCL cell lines to assist further lncRNA research in DLBCL. |
| first_indexed | 2024-04-11T11:23:35Z |
| format | Article |
| id | doaj.art-45ded4266a314572ac2484301bd5dc60 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-04-11T11:23:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-45ded4266a314572ac2484301bd5dc602022-12-22T04:26:30ZengMDPI AGNon-Coding RNA2311-553X2020-12-0171110.3390/ncrna7010001Long Non-Coding RNAs in Diffuse Large B-Cell LymphomaKasper Thystrup Karstensen0Aleks Schein1Andreas Petri2Martin Bøgsted3Karen Dybkær4Shizuka Uchida5Sakari Kauppinen6Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Medicine, Aalborg University, DK-9000 Aalborg, DenmarkDepartment of Clinical Medicine, Faculty of Medicine, Aalborg University, DK-9000 Aalborg, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, DenmarkDiffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Although significant progress has been made in recent years to treat DLBCL patients, 30%–40% of the patients eventually relapse or are refractory to first line treatment, calling for better therapeutic strategies for DLBCL. Long non-coding RNAs (lncRNAs) have emerged as a highly diverse group of non-protein coding transcripts with intriguing molecular functions in human disease, including cancer. Here, we review the current understanding of lncRNAs in the pathogenesis and progression of DLBCL to provide an overview of the field. As the current knowledge of lncRNAs in DLBCL is still in its infancy, we provide molecular signatures of lncRNAs in DLBCL cell lines to assist further lncRNA research in DLBCL.https://www.mdpi.com/2311-553X/7/1/1DLBCLlncRNAmiRNArituximab |
| spellingShingle | Kasper Thystrup Karstensen Aleks Schein Andreas Petri Martin Bøgsted Karen Dybkær Shizuka Uchida Sakari Kauppinen Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma Non-Coding RNA DLBCL lncRNA miRNA rituximab |
| title | Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma |
| title_full | Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma |
| title_fullStr | Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma |
| title_short | Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma |
| title_sort | long non coding rnas in diffuse large b cell lymphoma |
| topic | DLBCL lncRNA miRNA rituximab |
| url | https://www.mdpi.com/2311-553X/7/1/1 |
| work_keys_str_mv | AT kasperthystrupkarstensen longnoncodingrnasindiffuselargebcelllymphoma AT aleksschein longnoncodingrnasindiffuselargebcelllymphoma AT andreaspetri longnoncodingrnasindiffuselargebcelllymphoma AT martinbøgsted longnoncodingrnasindiffuselargebcelllymphoma AT karendybkær longnoncodingrnasindiffuselargebcelllymphoma AT shizukauchida longnoncodingrnasindiffuselargebcelllymphoma AT sakarikauppinen longnoncodingrnasindiffuselargebcelllymphoma |