Genetic and environmental risk factors of acute infection-triggered encephalopathy
Acute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1119708/full |
| _version_ | 1797944961928265728 |
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| author | Masashi Mizuguchi Masashi Mizuguchi Akiko Shibata Akiko Shibata Mariko Kasai Mariko Kasai Ai Hoshino Ai Hoshino |
| author_facet | Masashi Mizuguchi Masashi Mizuguchi Akiko Shibata Akiko Shibata Mariko Kasai Mariko Kasai Ai Hoshino Ai Hoshino |
| author_sort | Masashi Mizuguchi |
| collection | DOAJ |
| description | Acute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include pathogenic microorganisms of the antecedent infection such as influenza virus, human herpesvirus-6 and enterohemorrhagic Escherichia coli, and drugs such as non-steroidal anti-inflammatory drugs, valproate and theophylline. Genetic factors include mutations such as rare variants of the SCN1A and RANBP2 genes, and polymorphisms such as thermolabile CPT2 variants and HLA genotypes. By altering immune response, metabolism or neuronal excitation, these factors complicate the pathologic process. On the other hand, some of them could provide promising targets to prevent or treat acute encephalopathy. |
| first_indexed | 2024-04-10T20:47:50Z |
| format | Article |
| id | doaj.art-45df2a7427694a99807479bbd30ca249 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T20:47:50Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-45df2a7427694a99807479bbd30ca2492023-01-24T05:00:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-01-011710.3389/fnins.2023.11197081119708Genetic and environmental risk factors of acute infection-triggered encephalopathyMasashi Mizuguchi0Masashi Mizuguchi1Akiko Shibata2Akiko Shibata3Mariko Kasai4Mariko Kasai5Ai Hoshino6Ai Hoshino7Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Pediatrics, National Rehabilitation Center for Children With Disabilities, Tokyo, JapanDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanLaboratory for Brain Development and Disorders, RIKEN Center for Brain Science, Tokyo, JapanDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Pediatrics, Saitama Citizens Medical Center, Saitama, JapanDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Fuchu, JapanAcute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include pathogenic microorganisms of the antecedent infection such as influenza virus, human herpesvirus-6 and enterohemorrhagic Escherichia coli, and drugs such as non-steroidal anti-inflammatory drugs, valproate and theophylline. Genetic factors include mutations such as rare variants of the SCN1A and RANBP2 genes, and polymorphisms such as thermolabile CPT2 variants and HLA genotypes. By altering immune response, metabolism or neuronal excitation, these factors complicate the pathologic process. On the other hand, some of them could provide promising targets to prevent or treat acute encephalopathy.https://www.frontiersin.org/articles/10.3389/fnins.2023.1119708/fullacute encephalopathyinfectiondrugimmune responsemetabolismneuronal excitation |
| spellingShingle | Masashi Mizuguchi Masashi Mizuguchi Akiko Shibata Akiko Shibata Mariko Kasai Mariko Kasai Ai Hoshino Ai Hoshino Genetic and environmental risk factors of acute infection-triggered encephalopathy Frontiers in Neuroscience acute encephalopathy infection drug immune response metabolism neuronal excitation |
| title | Genetic and environmental risk factors of acute infection-triggered encephalopathy |
| title_full | Genetic and environmental risk factors of acute infection-triggered encephalopathy |
| title_fullStr | Genetic and environmental risk factors of acute infection-triggered encephalopathy |
| title_full_unstemmed | Genetic and environmental risk factors of acute infection-triggered encephalopathy |
| title_short | Genetic and environmental risk factors of acute infection-triggered encephalopathy |
| title_sort | genetic and environmental risk factors of acute infection triggered encephalopathy |
| topic | acute encephalopathy infection drug immune response metabolism neuronal excitation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1119708/full |
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