Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9 revealed the highest osteogenic potential compared to other BMPs, possibly due to its unique signaling pathways that differs from other osteogeni...

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Bibliographic Details
Main Authors: Claudia Siverino, Shorouk Fahmy-Garcia, Viktoria Niklaus, Nicole Kops, Laura Dolcini, Massimiliano Maraglino Misciagna, Yanto Ridwan, Eric Farrell, Gerjo J.V.M. van Osch, Joachim Nickel
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-11-01
Series:Bioactive Materials
Subjects:
Bone morphogenetic protein 9 (BMP9)
Heparin binding sites
Bone regeneration
Subcutaneous animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23002153

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