Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease
Vaccination relies on the phenomenon of immunity, a long-term change in the immunological response to subsequent encounters with the same pathogen that occurs after the recovery from some infectious diseases. However, vaccination is a strategy that can, in principle, be applied also to non-infectiou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/12/425 |
| _version_ | 1797546520934875136 |
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| author | Francesca Mantile Antonella Prisco |
| author_facet | Francesca Mantile Antonella Prisco |
| author_sort | Francesca Mantile |
| collection | DOAJ |
| description | Vaccination relies on the phenomenon of immunity, a long-term change in the immunological response to subsequent encounters with the same pathogen that occurs after the recovery from some infectious diseases. However, vaccination is a strategy that can, in principle, be applied also to non-infectious diseases, such as cancer or neurodegenerative diseases, if an adaptive immune response can prevent the onset of the disease or modify its course. Immunization against β-amyloid has been explored as a vaccination strategy for Alzheimer’s disease for over 20 years. No vaccine has been licensed so far, and immunotherapy has come under considerable criticism following the negative results of several phase III clinical trials. In this narrative review, we illustrate the working hypothesis behind immunization against β-amyloid as a vaccination strategy for Alzheimer’s disease, and the outcome of the active immunization strategies that have been tested in humans. On the basis of the lessons learned from preclinical and clinical research, we discuss roadblocks and current perspectives in this challenging enterprise in translational immunology. |
| first_indexed | 2024-03-10T14:30:58Z |
| format | Article |
| id | doaj.art-45e2b3b730d0406abb6d0762608cb470 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T14:30:58Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-45e2b3b730d0406abb6d0762608cb4702023-11-20T22:35:14ZengMDPI AGBiology2079-77372020-11-0191242510.3390/biology9120425Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s DiseaseFrancesca Mantile0Antonella Prisco1Institute of Genetics and Biophysics, CNR, 80131 Naples, ItalyInstitute of Genetics and Biophysics, CNR, 80131 Naples, ItalyVaccination relies on the phenomenon of immunity, a long-term change in the immunological response to subsequent encounters with the same pathogen that occurs after the recovery from some infectious diseases. However, vaccination is a strategy that can, in principle, be applied also to non-infectious diseases, such as cancer or neurodegenerative diseases, if an adaptive immune response can prevent the onset of the disease or modify its course. Immunization against β-amyloid has been explored as a vaccination strategy for Alzheimer’s disease for over 20 years. No vaccine has been licensed so far, and immunotherapy has come under considerable criticism following the negative results of several phase III clinical trials. In this narrative review, we illustrate the working hypothesis behind immunization against β-amyloid as a vaccination strategy for Alzheimer’s disease, and the outcome of the active immunization strategies that have been tested in humans. On the basis of the lessons learned from preclinical and clinical research, we discuss roadblocks and current perspectives in this challenging enterprise in translational immunology.https://www.mdpi.com/2079-7737/9/12/425vaccineAlzheimer’s diseaseβ-amyloidAN1792 |
| spellingShingle | Francesca Mantile Antonella Prisco Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease Biology vaccine Alzheimer’s disease β-amyloid AN1792 |
| title | Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease |
| title_full | Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease |
| title_fullStr | Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease |
| title_full_unstemmed | Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease |
| title_short | Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease |
| title_sort | vaccination against β amyloid as a strategy for the prevention of alzheimer s disease |
| topic | vaccine Alzheimer’s disease β-amyloid AN1792 |
| url | https://www.mdpi.com/2079-7737/9/12/425 |
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