Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke
Background: Ischemic stroke has a poor prognosis and brings a ponderous burden on families and society. Hemorrhagic transformation (HT) after intravenous thrombolysis can increase the mortality of patients with ischemic stroke. Thus, finding new HT biomarkers to be applicable in clinical practice is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.551157/full |
| _version_ | 1818096182384132096 |
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| author | Fan Sun Heng Liu Hui-xiao Fu Cheng-bo Li Xiao-jing Geng Xiao-xuan Zhang Jiang Zhu Zheng Ma Yan-jun Gao Zhi-jie Dou |
| author_facet | Fan Sun Heng Liu Hui-xiao Fu Cheng-bo Li Xiao-jing Geng Xiao-xuan Zhang Jiang Zhu Zheng Ma Yan-jun Gao Zhi-jie Dou |
| author_sort | Fan Sun |
| collection | DOAJ |
| description | Background: Ischemic stroke has a poor prognosis and brings a ponderous burden on families and society. Hemorrhagic transformation (HT) after intravenous thrombolysis can increase the mortality of patients with ischemic stroke. Thus, finding new HT biomarkers to be applicable in clinical practice is of great importance.Methods: The related risk factors were recruited for analysis, including smoking, drinking, hyperlipidemia, diabetes, anamnesis, and pathological indicators. Moreover, the relationship between serum levels of caveolin-1, caveolin-2, and HT after rt-PA treatment were also studied.Results: We studied 306 patients with acute ischemic stroke treated with recombinant tissue type plasminogen activator (rt-PA) within 4.5 h of symptom onset. The results showed that Age ≥68 years, smoking, Atrial fibrillation, NIHSS score before thrombolysis ≥17, and systolic pressure 2 h after thrombolysis (mmHg) ≥149 increased the risks of HT after rt-PA administration. Remarkably, the concentration of caveolin-1 (ng/mL) ≤ 0.12 and caveolin-2 (ng/mL) ≤ 0.43 in serum increased the risks of HT after rt-PA administration.Conclusion: Knowledge on the risk factors associated with HT after rt-PA treatment may help develop treatment strategies and reduce the risk of HT. Caveolin-1 and caveolin-2 can be predictors of HT after rt-PA administration. These findings provide evidence for future further investigations aimed to validate these biomarkers. |
| first_indexed | 2024-12-10T23:00:33Z |
| format | Article |
| id | doaj.art-45e2e13e093a49269a8c1abaef865e6d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T23:00:33Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-45e2e13e093a49269a8c1abaef865e6d2022-12-22T01:30:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-11-011110.3389/fneur.2020.551157551157Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic StrokeFan SunHeng LiuHui-xiao FuCheng-bo LiXiao-jing GengXiao-xuan ZhangJiang ZhuZheng MaYan-jun GaoZhi-jie DouBackground: Ischemic stroke has a poor prognosis and brings a ponderous burden on families and society. Hemorrhagic transformation (HT) after intravenous thrombolysis can increase the mortality of patients with ischemic stroke. Thus, finding new HT biomarkers to be applicable in clinical practice is of great importance.Methods: The related risk factors were recruited for analysis, including smoking, drinking, hyperlipidemia, diabetes, anamnesis, and pathological indicators. Moreover, the relationship between serum levels of caveolin-1, caveolin-2, and HT after rt-PA treatment were also studied.Results: We studied 306 patients with acute ischemic stroke treated with recombinant tissue type plasminogen activator (rt-PA) within 4.5 h of symptom onset. The results showed that Age ≥68 years, smoking, Atrial fibrillation, NIHSS score before thrombolysis ≥17, and systolic pressure 2 h after thrombolysis (mmHg) ≥149 increased the risks of HT after rt-PA administration. Remarkably, the concentration of caveolin-1 (ng/mL) ≤ 0.12 and caveolin-2 (ng/mL) ≤ 0.43 in serum increased the risks of HT after rt-PA administration.Conclusion: Knowledge on the risk factors associated with HT after rt-PA treatment may help develop treatment strategies and reduce the risk of HT. Caveolin-1 and caveolin-2 can be predictors of HT after rt-PA administration. These findings provide evidence for future further investigations aimed to validate these biomarkers.https://www.frontiersin.org/articles/10.3389/fneur.2020.551157/fullacute ischemic strokehemorrhagic transformation (HT)caveolin-1 (Cav-1)caveolin-2 (Cav-2)biomarkers |
| spellingShingle | Fan Sun Heng Liu Hui-xiao Fu Cheng-bo Li Xiao-jing Geng Xiao-xuan Zhang Jiang Zhu Zheng Ma Yan-jun Gao Zhi-jie Dou Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke Frontiers in Neurology acute ischemic stroke hemorrhagic transformation (HT) caveolin-1 (Cav-1) caveolin-2 (Cav-2) biomarkers |
| title | Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke |
| title_full | Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke |
| title_fullStr | Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke |
| title_full_unstemmed | Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke |
| title_short | Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke |
| title_sort | predictive factors of hemorrhage after thrombolysis in patients with acute ischemic stroke |
| topic | acute ischemic stroke hemorrhagic transformation (HT) caveolin-1 (Cav-1) caveolin-2 (Cav-2) biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.551157/full |
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