Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions
We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic cat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/6/11617 |
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| author | Elodie Brun Abdelmounaim Safer François Carreaux Khadidja Bourahla Jean-Martial L'helgoua'ch Jean-Pierre Bazureau Jose Manuel Villalgordo |
| author_facet | Elodie Brun Abdelmounaim Safer François Carreaux Khadidja Bourahla Jean-Martial L'helgoua'ch Jean-Pierre Bazureau Jose Manuel Villalgordo |
| author_sort | Elodie Brun |
| collection | DOAJ |
| description | We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups. |
| first_indexed | 2024-04-12T13:59:37Z |
| format | Article |
| id | doaj.art-45e388b91a134977aa0c4feeba952bd9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T13:59:37Z |
| publishDate | 2015-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-45e388b91a134977aa0c4feeba952bd92022-12-22T03:30:15ZengMDPI AGMolecules1420-30492015-06-01206116171163110.3390/molecules200611617molecules200611617Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free ConditionsElodie Brun0Abdelmounaim Safer1François Carreaux2Khadidja Bourahla3Jean-Martial L'helgoua'ch4Jean-Pierre Bazureau5Jose Manuel Villalgordo6Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, FranceLSOA—Laboratoire de Synthèse Organique Appliquée, Department of chemistry, Oran 1 University, 1524 Oran, AlgeriaInstitut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, FranceInstitut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, FranceInstitut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, FranceInstitut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, FranceVillapharma Research, Parque Tecnologico de Fuente Alamo, E-30320 Murcia, SpainWe here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups.http://www.mdpi.com/1420-3049/20/6/11617condensation reactionboric acidcatalysissolvent-freemicrowave |
| spellingShingle | Elodie Brun Abdelmounaim Safer François Carreaux Khadidja Bourahla Jean-Martial L'helgoua'ch Jean-Pierre Bazureau Jose Manuel Villalgordo Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions Molecules condensation reaction boric acid catalysis solvent-free microwave |
| title | Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions |
| title_full | Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions |
| title_fullStr | Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions |
| title_full_unstemmed | Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions |
| title_short | Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions |
| title_sort | microwave assisted condensation reactions of acetophenone derivatives and activated methylene compounds with aldehydes catalyzed by boric acid under solvent free conditions |
| topic | condensation reaction boric acid catalysis solvent-free microwave |
| url | http://www.mdpi.com/1420-3049/20/6/11617 |
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