A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows
The dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally versus subcutaneously administered meloxicam in early-lactation dairy cattle. The study was conducted a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/6/3/73 |
| _version_ | 1818778805127348224 |
|---|---|
| author | Daniel Shock Steven Roche Merle Olson |
| author_facet | Daniel Shock Steven Roche Merle Olson |
| author_sort | Daniel Shock |
| collection | DOAJ |
| description | The dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally versus subcutaneously administered meloxicam in early-lactation dairy cattle. The study was conducted at a commercial dairy herd in southwestern Ontario, Canada. Twelve postpartum cows were enrolled in the study, receiving either subcutaneous meloxicam (MET) at 0.5 mg/kg body weight (n = 6) or oral meloxicam (MOS) at a higher dose of 1.0 mg/kg body weight (n = 6) immediately following parturition. The predicted half-life (12.5 ± 2.0 vs. 28.5 ± 2.0 h), C<sub>max</sub> (1.59 ± 0.15 vs. 1.95 ± 0.16 μg/mL), T<sub>max</sub> (5.33 vs. 11.7 h), and AUC<sub>0→∞</sub> (39.6 ± 7.4 vs. 115.6 ± 19 h * µg/mL) differed significantly between MET and MOS cows, respectively. After controlling for the treatment group, first lactation cows had a significantly higher half-life (4.1 ± 2.1 h), C<sub>max</sub> (0.56 ± 0.2 µg/mL), and AUC<sub>0→∞</sub> (21.6 ± h * µg/mL) relative to second lactation or greater cows, respectively. Administration of meloxicam through the subcutaneous or oral route results in appreciable, dose-dependent systemic levels. |
| first_indexed | 2024-12-18T11:50:33Z |
| format | Article |
| id | doaj.art-45e6523192a74f6c937ec8e2a5f5c30a |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-18T11:50:33Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-45e6523192a74f6c937ec8e2a5f5c30a2022-12-21T21:09:11ZengMDPI AGVeterinary Sciences2306-73812019-09-01637310.3390/vetsci6030073vetsci6030073A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy CowsDaniel Shock0Steven Roche1Merle Olson2ACER Consulting, Guelph, ON N1G 5L3, CanadaACER Consulting, Guelph, ON N1G 5L3, CanadaAlberta Veterinary Laboratories, Calgary, AB T2E 6J7, CanadaThe dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally versus subcutaneously administered meloxicam in early-lactation dairy cattle. The study was conducted at a commercial dairy herd in southwestern Ontario, Canada. Twelve postpartum cows were enrolled in the study, receiving either subcutaneous meloxicam (MET) at 0.5 mg/kg body weight (n = 6) or oral meloxicam (MOS) at a higher dose of 1.0 mg/kg body weight (n = 6) immediately following parturition. The predicted half-life (12.5 ± 2.0 vs. 28.5 ± 2.0 h), C<sub>max</sub> (1.59 ± 0.15 vs. 1.95 ± 0.16 μg/mL), T<sub>max</sub> (5.33 vs. 11.7 h), and AUC<sub>0→∞</sub> (39.6 ± 7.4 vs. 115.6 ± 19 h * µg/mL) differed significantly between MET and MOS cows, respectively. After controlling for the treatment group, first lactation cows had a significantly higher half-life (4.1 ± 2.1 h), C<sub>max</sub> (0.56 ± 0.2 µg/mL), and AUC<sub>0→∞</sub> (21.6 ± h * µg/mL) relative to second lactation or greater cows, respectively. Administration of meloxicam through the subcutaneous or oral route results in appreciable, dose-dependent systemic levels.https://www.mdpi.com/2306-7381/6/3/73dairy cowmeloxicampharmacokineticsnon-steroidal anti-inflammatoryearly lactation |
| spellingShingle | Daniel Shock Steven Roche Merle Olson A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows Veterinary Sciences dairy cow meloxicam pharmacokinetics non-steroidal anti-inflammatory early lactation |
| title | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows |
| title_full | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows |
| title_fullStr | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows |
| title_full_unstemmed | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows |
| title_short | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows |
| title_sort | comparative pharmacokinetic analysis of oral and subcutaneous meloxicam administered to postpartum dairy cows |
| topic | dairy cow meloxicam pharmacokinetics non-steroidal anti-inflammatory early lactation |
| url | https://www.mdpi.com/2306-7381/6/3/73 |
| work_keys_str_mv | AT danielshock acomparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows AT stevenroche acomparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows AT merleolson acomparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows AT danielshock comparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows AT stevenroche comparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows AT merleolson comparativepharmacokineticanalysisoforalandsubcutaneousmeloxicamadministeredtopostpartumdairycows |