Cultivated autologous oral mucosal epithelial transplantation
According to the World Health Organization, corneal blindness is the fourth most common cause of blindness and visual impairment worldwide. In Russia, up to 18% of blindness is caused by corneal damage. Limbal stem cell deficiency (LSCD) is one of the causes of corneal blindness and visual impairmen...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-04-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1328 |
| _version_ | 1797871922801803264 |
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| author | S. A. Borzenok B. E. Malyugin M. Yu. Gerasimov D. S. Ostrovsky |
| author_facet | S. A. Borzenok B. E. Malyugin M. Yu. Gerasimov D. S. Ostrovsky |
| author_sort | S. A. Borzenok |
| collection | DOAJ |
| description | According to the World Health Organization, corneal blindness is the fourth most common cause of blindness and visual impairment worldwide. In Russia, up to 18% of blindness is caused by corneal damage. Limbal stem cell deficiency (LSCD) is one of the causes of corneal blindness and visual impairment due to anterior epithelial replacement with fibrovascular pannus. Bilateral LSCD may develop in patients with aniridia, Steven-Jones syndrome, and severe corneal burns of both eyes, leading to severe decrease in visual acuity in both eyes and, as a consequence, physical disability associated with blindness. In such cases, cell therapy, based on autologous oral epithelial culture as an alternative to allogeneic limbus transplants, is proposed for reconstruction of the anterior corneal epithelium. This new treatment method promotes corneal reepithelization, better visual acuity, reduced nonspecific ocular complaints and improved quality of life of patients. The effectiveness and significant increase in the frequency of transparent engraftment of donor corneas after cell therapy drives huge interest in this topic all over the world. This review presents literature data on the features of histotopography and methods for obtaining a cultured autologous oral mucosal epithelium, on cell markers that are used to identify epithelial cells, and on methods for creating cell grafts for subsequent transplantation to the corneal surface in LSCD patients. |
| first_indexed | 2024-04-10T00:51:49Z |
| format | Article |
| id | doaj.art-45e700384a2d4014a3ec2da03c1414e6 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:51:49Z |
| publishDate | 2021-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-45e700384a2d4014a3ec2da03c1414e62023-03-13T10:37:27ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912021-04-0123117117710.15825/1995-1191-2021-1-171-177969Cultivated autologous oral mucosal epithelial transplantationS. A. Borzenok0B. E. Malyugin1M. Yu. Gerasimov2D. S. Ostrovsky3Fyodorov Eye Microsurgery Federal State Institution; Evdokimov Moscow State University of Medicine and DentistryFyodorov Eye Microsurgery Federal State Institution; Evdokimov Moscow State University of Medicine and DentistryFyodorov Eye Microsurgery Federal State InstitutionFyodorov Eye Microsurgery Federal State InstitutionAccording to the World Health Organization, corneal blindness is the fourth most common cause of blindness and visual impairment worldwide. In Russia, up to 18% of blindness is caused by corneal damage. Limbal stem cell deficiency (LSCD) is one of the causes of corneal blindness and visual impairment due to anterior epithelial replacement with fibrovascular pannus. Bilateral LSCD may develop in patients with aniridia, Steven-Jones syndrome, and severe corneal burns of both eyes, leading to severe decrease in visual acuity in both eyes and, as a consequence, physical disability associated with blindness. In such cases, cell therapy, based on autologous oral epithelial culture as an alternative to allogeneic limbus transplants, is proposed for reconstruction of the anterior corneal epithelium. This new treatment method promotes corneal reepithelization, better visual acuity, reduced nonspecific ocular complaints and improved quality of life of patients. The effectiveness and significant increase in the frequency of transparent engraftment of donor corneas after cell therapy drives huge interest in this topic all over the world. This review presents literature data on the features of histotopography and methods for obtaining a cultured autologous oral mucosal epithelium, on cell markers that are used to identify epithelial cells, and on methods for creating cell grafts for subsequent transplantation to the corneal surface in LSCD patients.https://journal.transpl.ru/vtio/article/view/1328oral mucosal epithelial cellsoral epitheliumstem cell transplantationcorneacorneal epitheliumlimbal stem cell deficiency |
| spellingShingle | S. A. Borzenok B. E. Malyugin M. Yu. Gerasimov D. S. Ostrovsky Cultivated autologous oral mucosal epithelial transplantation Vestnik Transplantologii i Iskusstvennyh Organov oral mucosal epithelial cells oral epithelium stem cell transplantation cornea corneal epithelium limbal stem cell deficiency |
| title | Cultivated autologous oral mucosal epithelial transplantation |
| title_full | Cultivated autologous oral mucosal epithelial transplantation |
| title_fullStr | Cultivated autologous oral mucosal epithelial transplantation |
| title_full_unstemmed | Cultivated autologous oral mucosal epithelial transplantation |
| title_short | Cultivated autologous oral mucosal epithelial transplantation |
| title_sort | cultivated autologous oral mucosal epithelial transplantation |
| topic | oral mucosal epithelial cells oral epithelium stem cell transplantation cornea corneal epithelium limbal stem cell deficiency |
| url | https://journal.transpl.ru/vtio/article/view/1328 |
| work_keys_str_mv | AT saborzenok cultivatedautologousoralmucosalepithelialtransplantation AT bemalyugin cultivatedautologousoralmucosalepithelialtransplantation AT myugerasimov cultivatedautologousoralmucosalepithelialtransplantation AT dsostrovsky cultivatedautologousoralmucosalepithelialtransplantation |