Recent Advances in the Study of Na<sup>+</sup>/K<sup>+</sup>-ATPase in Neurodegenerative Diseases

Recent Advances in the Study of Na<sup>+</sup>/K<sup>+</sup>-ATPase in Neurodegenerative Diseases

Na<sup>+</sup>/K<sup>+</sup>-ATPase (NKA), a large transmembrane protein, is expressed in the plasma membrane of most eukaryotic cells. It maintains resting membrane potential, cell volume and secondary transcellular transport of other ions and neurotransmitters. NKA consumes...

Full description

Bibliographic Details
Main Authors:	Xiaoyan Zhang, Weithye Lee, Jin-Song Bian
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Cells
Subjects:	Na<sup>+</sup>/K<sup>+</sup>-ATPase neurodegenerative diseases protein–protein interaction mitochondrial dysfunction oxidative stress
Online Access:	https://www.mdpi.com/2073-4409/11/24/4075

Similar Items

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

Interaction of (+)-Strebloside and Its Derivatives with Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets
by: Yulin Ren, et al.
Published: (2021-09-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies
by: Alisa A. Markina, et al.
Published: (2023-06-01)

Na<sup>+</sup>/K<sup>+</sup>- and Mg<sup>2+</sup>-ATPases and Their Interaction with AMPA, NMDA and D<sub>2</sub> Dopamine Receptors in an Animal Model of Febrile Seizures
by: María Crespo, et al.
Published: (2022-11-01)

In Vitro Cell Sensitivity to Palytoxin Correlates with High Gene Expression of the Na<sup>+</sup>/K<sup>+</sup>-ATPase β2 Subunit Isoform
by: Marco Pelin, et al.
Published: (2020-08-01)

Structural Insights into the Interactions of Digoxin and Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
by: Yulin Ren, et al.
Published: (2021-06-01)

Ontogenetic Development of Gill and Na<sup>+</sup>/K<sup>+</sup> ATPase in the Air-Breathing Loach
by: Yaqiu Liu, et al.
Published: (2022-12-01)

Deficiency of Thyroid Hormone Reduces Voltage-Gated Na<sup>+</sup> Currents as Well as Expression of Na<sup>+</sup>/K<sup>+</sup>-ATPase in the Mouse Hippocampus
by: Sivaraj Mohana Sundaram, et al.
Published: (2022-04-01)

Maternal Caffeine Consumption during Gestation and Lactation Abolishes Cortical Oxidative Stress and Restores Na<sup>+</sup>/K<sup>+</sup>-ATPase Activity in Neonates Exposed to Hyperthermia-Induced Seizures
by: María Crespo, et al.
Published: (2023-12-01)

Effects of Electroporation on the Function of Sarco/Endoplasmic Reticulum Ca<sup>2+</sup>-ATPase and Na<sup>+</sup>,K<sup>+</sup>-ATPase in H9c2 Cells
by: Vid Jan, et al.
Published: (2024-03-01)

The β<sub>2</sub>-Subunit (AMOG) of Human Na<sup>+</sup>, K<sup>+</sup>-ATPase Is a Homophilic Adhesion Molecule
by: María Luisa Roldán, et al.
Published: (2022-07-01)

Na<sup>+</sup>, K<sup>+</sup>-ATPase α Isoforms and Endogenous Cardiac Steroids in Prefrontal Cortex of Bipolar Patients and Controls
by: Shiv Vardan Singh, et al.
Published: (2020-08-01)

Effect of Cell Cycle on Cell Surface Expression of Voltage-Gated Sodium Channels and Na<sup>+</sup>,K<sup>+</sup>-ATPase
by: Samantha Edenfield, et al.
Published: (2022-10-01)

Effects of Short-Term Salinity Stress on Ions, Free Amino Acids, Na<sup>+</sup>/K<sup>+</sup>-ATPase Activity, and Gill Histology in the Threatened Freshwater Shellfish <i>Solenaia oleivora</i>
by: Ting Zhang, et al.
Published: (2022-11-01)

Systemic Hypertension Effects on the Ciliary Body and Iris. An Immunofluorescence Study with Aquaporin 1, Aquaporin 4, and Na<sup>+</sup>, K<sup>+</sup> ATPase in Hypertensive Rats
by: Ibrahim González-Marrero, et al.
Published: (2018-11-01)

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na<sup>+</sup>,K<sup>+</sup>-ATPase α<sub>2</sub>-Isoform
by: Rajkumar Rajanathan, et al.
Published: (2023-04-01)

In Vitro Study of the Multimodal Effect of Na<sup>+</sup>/K<sup>+</sup> ATPase Blocker Ouabain on the Tumor Microenvironment and Malignant Cells
by: Octavia-Oana Harich, et al.
Published: (2023-08-01)

Evolution of Plant Na<sup>+</sup>-P-Type ATPases: From Saline Environments to Land Colonization
by: Siarhei A. Dabravolski, et al.
Published: (2021-01-01)

Involvement of the Na<sup>+</sup>, K<sup>+</sup>-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors
by: Noa Horesh, et al.
Published: (2024-01-01)

Transcriptomic Changes in Endothelial Cells Triggered by Na,K-ATPase Inhibition: A Search for Upstream Na<sup>+</sup><sub>i</sub>/K<sup>+</sup><sub>i</sub> Sensitive Genes
by: Elizaveta A. Klimanova, et al.
Published: (2020-10-01)

The effect of saponins from <it>Ampelozizyphus amazonicus</it> Ducke on the renal Na<sup>+</sup> pumps’ activities and urinary excretion of natriuretic peptides
by: Diniz Lúcio Ricardo, et al.
Published: (2012-04-01)

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H<sup>+</sup>/K<sup>+</sup>-ATPase Pump, Oxidative Stress and Inflammatory Pathways
by: Sidra Razzaq, et al.
Published: (2022-08-01)

Na<sup>+</sup>/K<sup>+</sup>-ATPase Alpha 2 Isoform Elicits Rac1-Dependent Oxidative Stress and TLR4-Induced Inflammation in the Hypothalamic Paraventricular Nucleus in High Salt-Induced Hypertension
by: Qing Su, et al.
Published: (2022-01-01)

Cloning and Characterization of Two Putative P-Type ATPases from the Marine Microalga <i>Dunaliella maritima</i> Similar to Plant H<sup>+</sup>-ATPases and Their Gene Expression Analysis under Conditions of Hyperosmotic Salt Shock
by: Dmitrii A. Matalin, et al.
Published: (2021-12-01)

Comparative Na<sup>+</sup> and K<sup>+</sup> Profiling Reveals Microbial Community Assembly of Alfalfa Silage in Different Saline-Alkali Soils
by: Shengnan Li, et al.
Published: (2023-09-01)

The Sweet Potato K<sup>+</sup> Transporter IbHAK11 Regulates K<sup>+</sup> Deficiency and High Salinity Stress Tolerance by Maintaining Positive Ion Homeostasis
by: Hong Zhu, et al.
Published: (2023-06-01)

Persimmon Leaves (<i>Diospyros kaki</i>) Extract Enhances the Viability of Human Corneal Endothelial Cells by Improving Na<sup>+</sup>-K<sup>+</sup>-ATPase Activity
by: Ramsha Afzal, et al.
Published: (2022-01-01)

The Non-Gastric H<sup>+</sup>/K<sup>+</sup> ATPase (ATP12A) Is Expressed in Mammalian Spermatozoa
by: Maria Favia, et al.
Published: (2022-01-01)

Characterization of Two Na<sup>+</sup>(K<sup>+</sup>, Li<sup>+</sup>)/H<sup>+</sup> Antiporters from <i>Natronorubrum daqingense</i>
by: Qi Wang, et al.
Published: (2023-06-01)

Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K<sup>+</sup>/Na<sup>+</sup> Selectivity in the Absence of Proteins
by: Xianfeng Zhou, et al.
Published: (2020-04-01)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

Inhibition of Voltage-Gated Na<sup>+</sup> Currents Exerted by KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea), an Inhibitor of Na<sup>+</sup>-Ca<sup>2+</sup> Exchanging Process
by: Sheng-Nan Wu, et al.
Published: (2023-01-01)

Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts
by: Ayako Takeuchi, et al.
Published: (2021-12-01)

Light-Regulated Transcription of a Mitochondrial-Targeted K<sup>+</sup> Channel
by: Anja J. Engel, et al.
Published: (2020-11-01)

Salt-Stress-Induced Ion Transport Contributes to K<sup>+</sup>/Na<sup>+</sup> Homeostasis in Roots of Ping’ou Hybrid Hazelnut
by: Da Luo, et al.
Published: (2023-08-01)

<i>Populus euphratica</i> Phospholipase Dδ Increases Salt Tolerance by Regulating K<sup>+</sup>/Na<sup>+</sup> and ROS Homeostasis in Arabidopsis
by: Ying Zhang, et al.
Published: (2022-04-01)

Amino Acids 563–566 of the Na<sup>+</sup>/H<sup>+</sup> Exchanger Isoform 1 C-Terminal Cytosolic Tail Prevent Protein Degradation and Stabilize Protein Expression and Activity
by: Xiuju Li, et al.
Published: (2020-03-01)

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na<sup>+</sup> and K<sup>+</sup> Currents
by: Ping-Chung Kuo, et al.
Published: (2020-07-01)

Na<sup>+</sup> Binding and Transport: Insights from Light-Driven Na<sup>+</sup>-Pumping Rhodopsin
by: Qifan Yang, et al.
Published: (2023-10-01)