DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

Abstract Background Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency to develop T2D in obesity cannot be explained by genetic variation alone—epigenetic mechanisms, such as DNA methylat...

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Bibliographic Details
Main Authors:	Paulina Baca, Francisco Barajas-Olmos, Elaheh Mirzaeicheshmeh, Carlos Zerrweck, Lizbeth Guilbert, Ernesto Carlos Sánchez, Marlen Flores-Huacuja, Rafael Villafán, Angélica Martínez-Hernández, Humberto García-Ortiz, Cecilia Contreras-Cubas, Federico Centeno-Cruz, Lorena Orozco
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-12-01
Series:	Nutrition & Diabetes
Online Access:	https://doi.org/10.1038/s41387-022-00228-w

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