Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View
This study aimed to examine the association of dopamine-related genes with mental and motor development and the gene-environment interaction in preterm and term children. A total of 201 preterm and 111 term children were examined for their development at 6, 12, 18, 24, and 36 months and were genotyp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00092/full |
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| author | Nai-Jia Yao Wu-Shiun Hsieh Chyi-Her Lin Ching-Ing Tseng Wan-Yu Lin Po-Hsiu Kuo Po-Hsiu Kuo Yen-Ting Yu Wei J. Chen Wei J. Chen Wei J. Chen Suh-Fang Jeng Suh-Fang Jeng |
| author_facet | Nai-Jia Yao Wu-Shiun Hsieh Chyi-Her Lin Ching-Ing Tseng Wan-Yu Lin Po-Hsiu Kuo Po-Hsiu Kuo Yen-Ting Yu Wei J. Chen Wei J. Chen Wei J. Chen Suh-Fang Jeng Suh-Fang Jeng |
| author_sort | Nai-Jia Yao |
| collection | DOAJ |
| description | This study aimed to examine the association of dopamine-related genes with mental and motor development and the gene-environment interaction in preterm and term children. A total of 201 preterm and 111 term children were examined for their development at 6, 12, 18, 24, and 36 months and were genotyped for 15 single-nucleotide polymorphisms (SNPs) in dopamine-related genes (DRD2, DRD3, DAT1, COMT, and MAOA). An independent sample of 256 preterm children was used for replication. Since the developmental age trends of preterm children differed from those of term children, the analyses were stratified by prematurity. Among the 8 SNPs on the MAOA gene examined in the whole learning sample, the results of linkage disequilibrium analysis indicated that they were located in one block (all D′ > 0.9), and rs2239448 was chosen as the tag (r2 > 0.85). In the analysis of individual SNPs in each dopamine-related gene, the tag SNP (rs2239448) in MAOA remained significantly associated with the mental scores of preterm children for the interaction with age trend (p < 0.0001; largest effect size of 0.65 at 24 months) after Bonferroni correction for multiple testing. Similar findings for rs2239448 were replicated in the independent sample (p = 0.026). However, none of the SNPs were associated with the motor scores of preterm children, and none were related to the mental or motor scores of term children. The genetic variants of the MAOA gene exert influence on mental development throughout early childhood for preterm, but not term, children. |
| first_indexed | 2024-12-10T06:12:08Z |
| format | Article |
| id | doaj.art-45ede5af3bdc416aae6fe8e591841599 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T06:12:08Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-45ede5af3bdc416aae6fe8e5918415992022-12-22T01:59:32ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-03-01810.3389/fped.2020.00092496067Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal ViewNai-Jia Yao0Wu-Shiun Hsieh1Chyi-Her Lin2Ching-Ing Tseng3Wan-Yu Lin4Po-Hsiu Kuo5Po-Hsiu Kuo6Yen-Ting Yu7Wei J. Chen8Wei J. Chen9Wei J. Chen10Suh-Fang Jeng11Suh-Fang Jeng12School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanCenters of Genomic and Precision Medicine, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanResearch Center for Genes, Environment and Human Health, National Taiwan University, Taipei, TaiwanSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, TaiwanCenters of Genomic and Precision Medicine, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, TaiwanSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, TaiwanPhysical Therapy Center, National Taiwan University, Taipei, TaiwanThis study aimed to examine the association of dopamine-related genes with mental and motor development and the gene-environment interaction in preterm and term children. A total of 201 preterm and 111 term children were examined for their development at 6, 12, 18, 24, and 36 months and were genotyped for 15 single-nucleotide polymorphisms (SNPs) in dopamine-related genes (DRD2, DRD3, DAT1, COMT, and MAOA). An independent sample of 256 preterm children was used for replication. Since the developmental age trends of preterm children differed from those of term children, the analyses were stratified by prematurity. Among the 8 SNPs on the MAOA gene examined in the whole learning sample, the results of linkage disequilibrium analysis indicated that they were located in one block (all D′ > 0.9), and rs2239448 was chosen as the tag (r2 > 0.85). In the analysis of individual SNPs in each dopamine-related gene, the tag SNP (rs2239448) in MAOA remained significantly associated with the mental scores of preterm children for the interaction with age trend (p < 0.0001; largest effect size of 0.65 at 24 months) after Bonferroni correction for multiple testing. Similar findings for rs2239448 were replicated in the independent sample (p = 0.026). However, none of the SNPs were associated with the motor scores of preterm children, and none were related to the mental or motor scores of term children. The genetic variants of the MAOA gene exert influence on mental development throughout early childhood for preterm, but not term, children.https://www.frontiersin.org/article/10.3389/fped.2020.00092/fulldopaminegeneticschild developmentcognitive developmentprematuritylongitudinal analysis |
| spellingShingle | Nai-Jia Yao Wu-Shiun Hsieh Chyi-Her Lin Ching-Ing Tseng Wan-Yu Lin Po-Hsiu Kuo Po-Hsiu Kuo Yen-Ting Yu Wei J. Chen Wei J. Chen Wei J. Chen Suh-Fang Jeng Suh-Fang Jeng Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View Frontiers in Pediatrics dopamine genetics child development cognitive development prematurity longitudinal analysis |
| title | Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View |
| title_full | Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View |
| title_fullStr | Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View |
| title_full_unstemmed | Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View |
| title_short | Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View |
| title_sort | interaction between prematurity and the maoa gene on mental development in children a longitudinal view |
| topic | dopamine genetics child development cognitive development prematurity longitudinal analysis |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00092/full |
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