Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?
The preventive situation of parasitosis, a global public health burden especially for developing countries, is not looking that good. Similar to other infections, vaccines would be the best choice for preventing and controlling parasitic infection. However, ideal antigenic molecules for vaccine deve...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252554/full |
| _version_ | 1797665256104787968 |
|---|---|
| author | Jinhang Zhu Jinhang Zhu Jiaxi Liu Chao Yan Dahui Wang Wei Pan |
| author_facet | Jinhang Zhu Jinhang Zhu Jiaxi Liu Chao Yan Dahui Wang Wei Pan |
| author_sort | Jinhang Zhu |
| collection | DOAJ |
| description | The preventive situation of parasitosis, a global public health burden especially for developing countries, is not looking that good. Similar to other infections, vaccines would be the best choice for preventing and controlling parasitic infection. However, ideal antigenic molecules for vaccine development have not been identified so far, resulting from the complicated life history and enormous genomes of the parasites. Furthermore, the suppression or down-regulation of anti-infectious immunity mediated by the parasites or their derived molecules can compromise the effect of parasitic vaccines. Comparing the early immune profiles of several parasites in the permissive and non-permissive hosts, a robust innate immune response is proposed to be a critical event to eliminate the parasites. Therefore, enhancing innate immunity may be essential for designing novel and effective parasitic vaccines. The newly emerging trained immunity (also termed innate immune memory) has been increasingly recognized to provide a novel perspective for vaccine development targeting innate immunity. This article reviews the current status of parasitic vaccines and anti-infectious immunity, as well as the conception, characteristics, and mechanisms of trained immunity and its research progress in Parasitology, highlighting the possible consideration of trained immunity in designing novel vaccines against parasitic diseases. |
| first_indexed | 2024-03-11T19:41:19Z |
| format | Article |
| id | doaj.art-45ee495a23534e819e173c7426c09537 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T19:41:19Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-45ee495a23534e819e173c7426c095372023-10-06T09:53:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12525541252554Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?Jinhang Zhu0Jinhang Zhu1Jiaxi Liu2Chao Yan3Dahui Wang4Wei Pan5Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaThe Second Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaLiangshan College (Li Shui) China, Lishui University, Lishui, Zhejiang, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaThe preventive situation of parasitosis, a global public health burden especially for developing countries, is not looking that good. Similar to other infections, vaccines would be the best choice for preventing and controlling parasitic infection. However, ideal antigenic molecules for vaccine development have not been identified so far, resulting from the complicated life history and enormous genomes of the parasites. Furthermore, the suppression or down-regulation of anti-infectious immunity mediated by the parasites or their derived molecules can compromise the effect of parasitic vaccines. Comparing the early immune profiles of several parasites in the permissive and non-permissive hosts, a robust innate immune response is proposed to be a critical event to eliminate the parasites. Therefore, enhancing innate immunity may be essential for designing novel and effective parasitic vaccines. The newly emerging trained immunity (also termed innate immune memory) has been increasingly recognized to provide a novel perspective for vaccine development targeting innate immunity. This article reviews the current status of parasitic vaccines and anti-infectious immunity, as well as the conception, characteristics, and mechanisms of trained immunity and its research progress in Parasitology, highlighting the possible consideration of trained immunity in designing novel vaccines against parasitic diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252554/fullparasitic diseasesvaccinetrained immunityinnate immune memorymetabolic and epigenetic programming |
| spellingShingle | Jinhang Zhu Jinhang Zhu Jiaxi Liu Chao Yan Dahui Wang Wei Pan Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? Frontiers in Immunology parasitic diseases vaccine trained immunity innate immune memory metabolic and epigenetic programming |
| title | Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? |
| title_full | Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? |
| title_fullStr | Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? |
| title_full_unstemmed | Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? |
| title_short | Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases? |
| title_sort | trained immunity a cutting edge approach for designing novel vaccines against parasitic diseases |
| topic | parasitic diseases vaccine trained immunity innate immune memory metabolic and epigenetic programming |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252554/full |
| work_keys_str_mv | AT jinhangzhu trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases AT jinhangzhu trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases AT jiaxiliu trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases AT chaoyan trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases AT dahuiwang trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases AT weipan trainedimmunityacuttingedgeapproachfordesigningnovelvaccinesagainstparasiticdiseases |