Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review
The concept of using plants to alleviate diseases is always challenging. In West Java, Indonesia, a local plant, named dadap serep has been traditionally used to reduce blood glucose, fever, and edema, by pounding the leaves and applying them on the inflamed skin, or boiled and consumed as herbal te...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1281150/full |
| _version_ | 1827752587380654080 |
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| author | Elis Susilawati Elis Susilawati Jutti Levita Yasmiwar Susilawati Sri Adi Sumiwi |
| author_facet | Elis Susilawati Elis Susilawati Jutti Levita Yasmiwar Susilawati Sri Adi Sumiwi |
| author_sort | Elis Susilawati |
| collection | DOAJ |
| description | The concept of using plants to alleviate diseases is always challenging. In West Java, Indonesia, a local plant, named dadap serep has been traditionally used to reduce blood glucose, fever, and edema, by pounding the leaves and applying them on the inflamed skin, or boiled and consumed as herbal tea. This plant belongs to the Erythrina genus, which covers approximately 120 species. The scope of this review (1943–2023) is related to the Global Development Goals, in particular Goal 3: Good Health and Wellbeing, by focusing on the pharmacology activity, toxicity, and clinical trials of Erythrina genus plants and their metabolites, e.g., pterocarpans, alkaloids, and flavonoids. Articles were searched on PubMed and ScienceDirect databases, using “Erythrina” AND “pharmacology activity” keywords, and only original articles written in English and open access were included. In vitro and in vivo studies reveal promising results, particularly for antibacterial and anticancer activities. The toxicity and clinical studies of Erythrina genus plants are limitedly reported. Considering that extensive caution should be taken when prescribing botanical drugs for patients parallelly taking a narrow therapeutic window drug, it is confirmed that no interactions of the Erythrina genus were recorded, indicating the safety of the studied plants. We, therefore, concluded that Erythrina genus plants are promising to be further explored for their effects in various signaling pathways as future plant-based drug candidates. |
| first_indexed | 2024-03-11T07:21:25Z |
| format | Article |
| id | doaj.art-45f140f66f0d44d9abc1fa263ba271db |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T07:21:25Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-45f140f66f0d44d9abc1fa263ba271db2023-11-17T07:55:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12811501281150Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based reviewElis Susilawati0Elis Susilawati1Jutti Levita2Yasmiwar Susilawati3Sri Adi Sumiwi4Doctoral Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, IndonesiaFaculty of Pharmacy, Bhakti Kencana University, Bandung, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, IndonesiaDepartment of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, IndonesiaThe concept of using plants to alleviate diseases is always challenging. In West Java, Indonesia, a local plant, named dadap serep has been traditionally used to reduce blood glucose, fever, and edema, by pounding the leaves and applying them on the inflamed skin, or boiled and consumed as herbal tea. This plant belongs to the Erythrina genus, which covers approximately 120 species. The scope of this review (1943–2023) is related to the Global Development Goals, in particular Goal 3: Good Health and Wellbeing, by focusing on the pharmacology activity, toxicity, and clinical trials of Erythrina genus plants and their metabolites, e.g., pterocarpans, alkaloids, and flavonoids. Articles were searched on PubMed and ScienceDirect databases, using “Erythrina” AND “pharmacology activity” keywords, and only original articles written in English and open access were included. In vitro and in vivo studies reveal promising results, particularly for antibacterial and anticancer activities. The toxicity and clinical studies of Erythrina genus plants are limitedly reported. Considering that extensive caution should be taken when prescribing botanical drugs for patients parallelly taking a narrow therapeutic window drug, it is confirmed that no interactions of the Erythrina genus were recorded, indicating the safety of the studied plants. We, therefore, concluded that Erythrina genus plants are promising to be further explored for their effects in various signaling pathways as future plant-based drug candidates.https://www.frontiersin.org/articles/10.3389/fphar.2023.1281150/fullanti-inflammatoryErythrina genusflavonoidspterocarpanstoxicity |
| spellingShingle | Elis Susilawati Elis Susilawati Jutti Levita Yasmiwar Susilawati Sri Adi Sumiwi Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review Frontiers in Pharmacology anti-inflammatory Erythrina genus flavonoids pterocarpans toxicity |
| title | Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review |
| title_full | Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review |
| title_fullStr | Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review |
| title_full_unstemmed | Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review |
| title_short | Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review |
| title_sort | pharmacology activity toxicity and clinical trials of erythrina genus plants fabaceae an evidence based review |
| topic | anti-inflammatory Erythrina genus flavonoids pterocarpans toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1281150/full |
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