Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma
Sungungual keratoacanthoma is a rare and more aggressive variant of keratoacanthoma. The authors present a case of a 49-year-old male with a one year history of a growing exophytic nodule on the nail bed of the left first toe. Physical examination revealed a two centimeters large exofitic nodule wit...
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| Format: | Article |
| Language: | English |
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Sociedade Portuguesa de Dermatologia e Venereologia
2018-12-01
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| Series: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| Subjects: | |
| Online Access: | https://revista.spdv.com.pt/index.php/spdv/article/view/922 |
| _version_ | 1818155617145061376 |
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| author | Alexandre Miroux Catarino Maria Goreti Catorze Isabel Viana |
| author_facet | Alexandre Miroux Catarino Maria Goreti Catorze Isabel Viana |
| author_sort | Alexandre Miroux Catarino |
| collection | DOAJ |
| description | Sungungual keratoacanthoma is a rare and more aggressive variant of keratoacanthoma. The authors present a case of a 49-year-old male with a one year history of a growing exophytic nodule on the nail bed of the left first toe. Physical examination revealed a two centimeters large exofitic nodule with a verrucous hyperkeratotic central area on the nail bed. A plain radiograph showed a cup-shaped lytic defect in the underlying distal phalanx. Histopathologic analysis revealed a large crater-like squamoproliferative lesion, connected to the epidermis and consisting of lobules and nests of glassy epithelium with numerous dyskeratotic cells, very little degree of cytological atypia and low mitotic activity. Lymphovascular, perineural or bone invasion were not found. Immunohistochemistry with p53 and Ki67 showed exclusive focal basal staining. The diagnosis of subungual keratoacanthoma was made. The main differential diagnosis, both clinical and histological, is with squamous cell carcinoma. It is important to consider this entity to avoid unnecessary diagnostic delays and mutilating treatments. |
| first_indexed | 2024-12-11T14:45:15Z |
| format | Article |
| id | doaj.art-45f1b5ecb1184e848e3e53c95dbb59c0 |
| institution | Directory Open Access Journal |
| issn | 2182-2395 2182-2409 |
| language | English |
| last_indexed | 2024-12-11T14:45:15Z |
| publishDate | 2018-12-01 |
| publisher | Sociedade Portuguesa de Dermatologia e Venereologia |
| record_format | Article |
| series | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| spelling | doaj.art-45f1b5ecb1184e848e3e53c95dbb59c02022-12-22T01:01:44ZengSociedade Portuguesa de Dermatologia e VenereologiaRevista da Sociedade Portuguesa de Dermatologia e Venereologia2182-23952182-24092018-12-0176410.29021/spdv.76.4.922Subungual Keratoacanthoma: A Rare Variant of KeratoacanthomaAlexandre Miroux Catarino0Maria Goreti Catorze1Isabel Viana2Médico Interno de Dermatovenereologia/Resident of Dermatology and Venereology, Serviço de Dermatologia, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalAssistente Hospitalar Graduada de Dermatovenereologia, Serviço de Dermatologia, Centro Hospitalar de Lisboa Ocidental, Lisboa, PortugalAssistente Hospitalar Graduada de Dermatovenereologia, Serviço de Dermatologia, Centro Hospitalar de Lisboa Ocidental, Lisboa, PortugalSungungual keratoacanthoma is a rare and more aggressive variant of keratoacanthoma. The authors present a case of a 49-year-old male with a one year history of a growing exophytic nodule on the nail bed of the left first toe. Physical examination revealed a two centimeters large exofitic nodule with a verrucous hyperkeratotic central area on the nail bed. A plain radiograph showed a cup-shaped lytic defect in the underlying distal phalanx. Histopathologic analysis revealed a large crater-like squamoproliferative lesion, connected to the epidermis and consisting of lobules and nests of glassy epithelium with numerous dyskeratotic cells, very little degree of cytological atypia and low mitotic activity. Lymphovascular, perineural or bone invasion were not found. Immunohistochemistry with p53 and Ki67 showed exclusive focal basal staining. The diagnosis of subungual keratoacanthoma was made. The main differential diagnosis, both clinical and histological, is with squamous cell carcinoma. It is important to consider this entity to avoid unnecessary diagnostic delays and mutilating treatments.https://revista.spdv.com.pt/index.php/spdv/article/view/922KeratoacanthomaNail Diseases |
| spellingShingle | Alexandre Miroux Catarino Maria Goreti Catorze Isabel Viana Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma Revista da Sociedade Portuguesa de Dermatologia e Venereologia Keratoacanthoma Nail Diseases |
| title | Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma |
| title_full | Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma |
| title_fullStr | Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma |
| title_full_unstemmed | Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma |
| title_short | Subungual Keratoacanthoma: A Rare Variant of Keratoacanthoma |
| title_sort | subungual keratoacanthoma a rare variant of keratoacanthoma |
| topic | Keratoacanthoma Nail Diseases |
| url | https://revista.spdv.com.pt/index.php/spdv/article/view/922 |
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