Peptide hydrogel based sponge patch for wound infection treatment
Dressing with the function of anti-wound infection and promoting skin repair plays an important role in medicine, beauty industry, etc. In terms of anti-wound infection, traditional dressings, such as gauze, have problems such as excessive bleeding in the process of contact or removal, and slow woun...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066306/full |
| _version_ | 1828116321602109440 |
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| author | Lanxin Li Yuan Zhou Yuan Zhou Peizhe Li Qi Xu Kaiyan Li Hai Hu Wei Bing Zhijun Zhang |
| author_facet | Lanxin Li Yuan Zhou Yuan Zhou Peizhe Li Qi Xu Kaiyan Li Hai Hu Wei Bing Zhijun Zhang |
| author_sort | Lanxin Li |
| collection | DOAJ |
| description | Dressing with the function of anti-wound infection and promoting skin repair plays an important role in medicine, beauty industry, etc. In terms of anti-wound infection, traditional dressings, such as gauze, have problems such as excessive bleeding in the process of contact or removal, and slow wound healing due to poor biological compatibility. The development of new functional and biocompatible dressings has essential application value in biomedical fields. In this study, a new type of dressing based on polypeptide functional sponge patch was constructed. The porous sponge patch is made of antimicrobial peptide and medical agarose through gel and freeze-drying technology. In vitro antibacterial experiments and small animal skin wound infection model experiments show that the porous sponge has excellent antibacterial and anti-skin infection activities, as well as the function of promoting wound healing. |
| first_indexed | 2024-04-11T12:55:00Z |
| format | Article |
| id | doaj.art-45f1cb5b540f44dc851cda240e29b538 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T12:55:00Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-45f1cb5b540f44dc851cda240e29b5382022-12-22T04:23:06ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.10663061066306Peptide hydrogel based sponge patch for wound infection treatmentLanxin Li0Yuan Zhou1Yuan Zhou2Peizhe Li3Qi Xu4Kaiyan Li5Hai Hu6Wei Bing7Zhijun Zhang8School of Chemistry and Life Science, Changchun University of Technology, Changchun, ChinaDepartment of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaCollege of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan, ChinaKey Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaShanghai Beautyart Biotechnology Co., Ltd., Shanghai, ChinaShanghai Beautyart Biotechnology Co., Ltd., Shanghai, ChinaShanghai Beautyart Biotechnology Co., Ltd., Shanghai, ChinaSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, ChinaKey Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaDressing with the function of anti-wound infection and promoting skin repair plays an important role in medicine, beauty industry, etc. In terms of anti-wound infection, traditional dressings, such as gauze, have problems such as excessive bleeding in the process of contact or removal, and slow wound healing due to poor biological compatibility. The development of new functional and biocompatible dressings has essential application value in biomedical fields. In this study, a new type of dressing based on polypeptide functional sponge patch was constructed. The porous sponge patch is made of antimicrobial peptide and medical agarose through gel and freeze-drying technology. In vitro antibacterial experiments and small animal skin wound infection model experiments show that the porous sponge has excellent antibacterial and anti-skin infection activities, as well as the function of promoting wound healing.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066306/fullpeptide hydrogelsponge patchbacterial infectionwound healingmedical dressings |
| spellingShingle | Lanxin Li Yuan Zhou Yuan Zhou Peizhe Li Qi Xu Kaiyan Li Hai Hu Wei Bing Zhijun Zhang Peptide hydrogel based sponge patch for wound infection treatment Frontiers in Bioengineering and Biotechnology peptide hydrogel sponge patch bacterial infection wound healing medical dressings |
| title | Peptide hydrogel based sponge patch for wound infection treatment |
| title_full | Peptide hydrogel based sponge patch for wound infection treatment |
| title_fullStr | Peptide hydrogel based sponge patch for wound infection treatment |
| title_full_unstemmed | Peptide hydrogel based sponge patch for wound infection treatment |
| title_short | Peptide hydrogel based sponge patch for wound infection treatment |
| title_sort | peptide hydrogel based sponge patch for wound infection treatment |
| topic | peptide hydrogel sponge patch bacterial infection wound healing medical dressings |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066306/full |
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