Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery
Here we have reported a new protocol for drug delivery from hollow sphere manganese ferrite nanoparticles (HMF NPs). The crystalline structure of HMF NPs is obtained from XRD measurement and the morphological and elemental analysis are obtained from FESEM & TEM measurements. Here the HMF NPs are...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2022-01-01
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| Series: | 4 open |
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| Online Access: | https://www.4open-sciences.org/articles/fopen/full_html/2022/01/fopen220016/fopen220016.html |
| _version_ | 1797997044555579392 |
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| author | Mandal Goswami Madhuri De Debarati |
| author_facet | Mandal Goswami Madhuri De Debarati |
| author_sort | Mandal Goswami Madhuri |
| collection | DOAJ |
| description | Here we have reported a new protocol for drug delivery from hollow sphere manganese ferrite nanoparticles (HMF NPs). The crystalline structure of HMF NPs is obtained from XRD measurement and the morphological and elemental analysis are obtained from FESEM & TEM measurements. Here the HMF NPs are properly designed for delivery of dopamine (DA) as anticancer drug to cancer site. The DA polymerizes to a giant molecule polydopamine (PDA) inside hollow HMF in presence of TRIS buffer at pH (8.5) and a composite, HMF-PDA is formed. Being giant molecule polydopamine remain stable inside the hollow particles, but when these HMF-PDA come in contact of low pH i.e. pH 5 (cancer cells pH), free DA starts to be released. At hyperthermic temperature (45 °C) release enhances compare to physiological temperature (37 °C). The DA release studies are monitored by UV-visible absorption spectroscopy with progress of time at different temperatures and pH. It has been observed that HMF-PDA has fluorescent property whereas DA has no such effects. So, incorporation of PDA inside HMF and tagging of HMF-PDA with cancer cells can also be monitored by fluorescence imaging. Hence, we have successfully synthesized trifunctional HMF-PDA composite which can serve three purposes like cancer cell probing by fluorescence imaging, hyperthermia therapy and drug delivery by magnetic field and pH trigger method. |
| first_indexed | 2024-04-11T10:26:53Z |
| format | Article |
| id | doaj.art-45f465a985164b0abe1571fbd9259648 |
| institution | Directory Open Access Journal |
| issn | 2557-0250 |
| language | English |
| last_indexed | 2024-04-11T10:26:53Z |
| publishDate | 2022-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | 4 open |
| spelling | doaj.art-45f465a985164b0abe1571fbd92596482022-12-22T04:29:33ZengEDP Sciences4 open2557-02502022-01-0151710.1051/fopen/2022018fopen220016Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug deliveryMandal Goswami Madhuri0https://orcid.org/0000-0002-4955-7219De Debarati1Centre for Biomedical Research, Bharat Sevashram Sangha HospitalCRNN, Calcutta UniversityHere we have reported a new protocol for drug delivery from hollow sphere manganese ferrite nanoparticles (HMF NPs). The crystalline structure of HMF NPs is obtained from XRD measurement and the morphological and elemental analysis are obtained from FESEM & TEM measurements. Here the HMF NPs are properly designed for delivery of dopamine (DA) as anticancer drug to cancer site. The DA polymerizes to a giant molecule polydopamine (PDA) inside hollow HMF in presence of TRIS buffer at pH (8.5) and a composite, HMF-PDA is formed. Being giant molecule polydopamine remain stable inside the hollow particles, but when these HMF-PDA come in contact of low pH i.e. pH 5 (cancer cells pH), free DA starts to be released. At hyperthermic temperature (45 °C) release enhances compare to physiological temperature (37 °C). The DA release studies are monitored by UV-visible absorption spectroscopy with progress of time at different temperatures and pH. It has been observed that HMF-PDA has fluorescent property whereas DA has no such effects. So, incorporation of PDA inside HMF and tagging of HMF-PDA with cancer cells can also be monitored by fluorescence imaging. Hence, we have successfully synthesized trifunctional HMF-PDA composite which can serve three purposes like cancer cell probing by fluorescence imaging, hyperthermia therapy and drug delivery by magnetic field and pH trigger method.https://www.4open-sciences.org/articles/fopen/full_html/2022/01/fopen220016/fopen220016.htmlhollow manganese ferrite nanoparticlesdrug deliverydopamineph and temperature responsive |
| spellingShingle | Mandal Goswami Madhuri De Debarati Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery 4 open hollow manganese ferrite nanoparticles drug delivery dopamine ph and temperature responsive |
| title | Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery |
| title_full | Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery |
| title_fullStr | Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery |
| title_full_unstemmed | Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery |
| title_short | Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery |
| title_sort | trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy cell probing and drug delivery |
| topic | hollow manganese ferrite nanoparticles drug delivery dopamine ph and temperature responsive |
| url | https://www.4open-sciences.org/articles/fopen/full_html/2022/01/fopen220016/fopen220016.html |
| work_keys_str_mv | AT mandalgoswamimadhuri trifunctionalfluorescentmanganeseferritenanoparticlesforhyperthermiatherapycellprobinganddrugdelivery AT dedebarati trifunctionalfluorescentmanganeseferritenanoparticlesforhyperthermiatherapycellprobinganddrugdelivery |