Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria
Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018,...
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| Format: | Article |
| Language: | English |
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The Korean Academy of Tuberculosis and Respiratory Diseases
2022-04-01
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| Series: | Tuberculosis and Respiratory Diseases |
| Subjects: | |
| Online Access: | http://www.e-trd.org/upload/pdf/trd-2021-0122.pdf |
| _version_ | 1811271895944790016 |
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| author | Amaylia Oehadian Prayudi Santoso Dick Menzies Rovina Ruslami |
| author_facet | Amaylia Oehadian Prayudi Santoso Dick Menzies Rovina Ruslami |
| author_sort | Amaylia Oehadian |
| collection | DOAJ |
| description | Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018, the World Health Organization revised the groupings of TB medicines and reclassified linezolid as a group A drug for the treatment of MDR-TB. Linezolid is a synthetic antimicrobial agent in the oxazolidinone class. Although linezolid has a good efficacy, it can cause substantial adverse events, especially hematologic toxicity. In both TB infection and linezolid mechanism of action, mitochondrial dysfunction plays an important role. In this concise review, characteristics of linezolid as an anti-TB drug are summarized, including its efficacy, pathogenesis of hematologic toxicity highlighting mitochondrial dysfunction, and the monitoring and management of hematologic toxicity. |
| first_indexed | 2024-04-12T22:30:26Z |
| format | Article |
| id | doaj.art-45f57439077f4ca189ad01141c1b73ae |
| institution | Directory Open Access Journal |
| issn | 1738-3536 2005-6184 |
| language | English |
| last_indexed | 2024-04-12T22:30:26Z |
| publishDate | 2022-04-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj.art-45f57439077f4ca189ad01141c1b73ae2022-12-22T03:13:59ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842022-04-0185211112110.4046/trd.2021.01224609Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of MitochondriaAmaylia Oehadian0Prayudi Santoso1Dick Menzies2Rovina Ruslami3 Division of Hematology and Oncology Medic, Department of Internal Medicine Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Division of Hematology and Oncology Medic, Department of Internal Medicine Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia McGill International TB Centre Respiratory Epidemiology and Clinical Research Unit, Montreal, Canada Division of Pharmacology, Department of Biomedical Science, Padjadjaran University/Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaMultidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018, the World Health Organization revised the groupings of TB medicines and reclassified linezolid as a group A drug for the treatment of MDR-TB. Linezolid is a synthetic antimicrobial agent in the oxazolidinone class. Although linezolid has a good efficacy, it can cause substantial adverse events, especially hematologic toxicity. In both TB infection and linezolid mechanism of action, mitochondrial dysfunction plays an important role. In this concise review, characteristics of linezolid as an anti-TB drug are summarized, including its efficacy, pathogenesis of hematologic toxicity highlighting mitochondrial dysfunction, and the monitoring and management of hematologic toxicity.http://www.e-trd.org/upload/pdf/trd-2021-0122.pdfmdr-tbxdr-tblinezolidhematologic toxicitymitochondria |
| spellingShingle | Amaylia Oehadian Prayudi Santoso Dick Menzies Rovina Ruslami Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria Tuberculosis and Respiratory Diseases mdr-tb xdr-tb linezolid hematologic toxicity mitochondria |
| title | Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria |
| title_full | Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria |
| title_fullStr | Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria |
| title_full_unstemmed | Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria |
| title_short | Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria |
| title_sort | concise clinical review of hematologic toxicity of linezolid in multidrug resistant and extensively drug resistant tuberculosis role of mitochondria |
| topic | mdr-tb xdr-tb linezolid hematologic toxicity mitochondria |
| url | http://www.e-trd.org/upload/pdf/trd-2021-0122.pdf |
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