Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study
Abstract Background The link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR g...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Nutrition Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12937-020-00572-6 |
| _version_ | 1828433791636471808 |
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| author | Monika A. Mlodzik-Czyzewska Anna M. Malinowska Agata Chmurzynska |
| author_facet | Monika A. Mlodzik-Czyzewska Anna M. Malinowska Agata Chmurzynska |
| author_sort | Monika A. Mlodzik-Czyzewska |
| collection | DOAJ |
| description | Abstract Background The link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. Methods A case–control study including 421 healthy participants (aged 20–40) was performed in Poznań, Poland. The cases were 213 subjects with BMI > 25 kg/m2, while the controls were 208 subjects with BMI < 25 kg/m2. Genotyping of rs70991108 (DHFR) and rs1801133 (MTHFR) was performed using TaqMan probes. Serum folate concentrations were measured using an enzyme-linked immunosorbent assay and homocysteine was assessed with high performance liquid chromatography. Results Subjects with overweight and obesity had 12% lower folate intake (p < 0.05) and 8.5% lower folate serum concentrations (p < 0.01) than the controls. Serum folate concentrations and folate intake were inversely associated with body fat percentage (p < 0.05) and waist circumference (p < 0.05 and p < 0.001, respectively). Serum folate concentration, though not folate intake, was negatively associated with WHR and BMI (p < 0.05, for both associations). Conclusions Lower folate intake and serum levels are weakly, but independently, associated with greater body weight and central adiposity in people aged 20–40. MTHFR and DHFR polymorphism seems not to have significant impact on body weight. |
| first_indexed | 2024-12-10T18:40:48Z |
| format | Article |
| id | doaj.art-45f5a26aadaf446e8f61f98e5970e1ea |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-10T18:40:48Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-45f5a26aadaf446e8f61f98e5970e1ea2022-12-22T01:37:40ZengBMCNutrition Journal1475-28912020-06-011911810.1186/s12937-020-00572-6Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control studyMonika A. Mlodzik-Czyzewska0Anna M. Malinowska1Agata Chmurzynska2Institute of Human Nutrition and Dietetics, Poznań University of Life SciencesInstitute of Human Nutrition and Dietetics, Poznań University of Life SciencesInstitute of Human Nutrition and Dietetics, Poznań University of Life SciencesAbstract Background The link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. Methods A case–control study including 421 healthy participants (aged 20–40) was performed in Poznań, Poland. The cases were 213 subjects with BMI > 25 kg/m2, while the controls were 208 subjects with BMI < 25 kg/m2. Genotyping of rs70991108 (DHFR) and rs1801133 (MTHFR) was performed using TaqMan probes. Serum folate concentrations were measured using an enzyme-linked immunosorbent assay and homocysteine was assessed with high performance liquid chromatography. Results Subjects with overweight and obesity had 12% lower folate intake (p < 0.05) and 8.5% lower folate serum concentrations (p < 0.01) than the controls. Serum folate concentrations and folate intake were inversely associated with body fat percentage (p < 0.05) and waist circumference (p < 0.05 and p < 0.001, respectively). Serum folate concentration, though not folate intake, was negatively associated with WHR and BMI (p < 0.05, for both associations). Conclusions Lower folate intake and serum levels are weakly, but independently, associated with greater body weight and central adiposity in people aged 20–40. MTHFR and DHFR polymorphism seems not to have significant impact on body weight.http://link.springer.com/article/10.1186/s12937-020-00572-6FolateBody weightBody fatMTHFRDHFR |
| spellingShingle | Monika A. Mlodzik-Czyzewska Anna M. Malinowska Agata Chmurzynska Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study Nutrition Journal Folate Body weight Body fat MTHFR DHFR |
| title | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study |
| title_full | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study |
| title_fullStr | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study |
| title_full_unstemmed | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study |
| title_short | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study |
| title_sort | low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation a case control study |
| topic | Folate Body weight Body fat MTHFR DHFR |
| url | http://link.springer.com/article/10.1186/s12937-020-00572-6 |
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