Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice
Obesity is an inflammatory disease associated with secondary diseases such as kidney disease, which can cause lipotoxicity, inflammation and loss of organ function. Polyunsaturated fatty acids act in the production of lipid mediators and have anti-inflammatory characteristics. In this work, the obje...
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MDPI AG
2023-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/13/2925 |
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| author | Priscila G. Pereira Luciana L. Alves Bianca T. Ciambarella Kíssila Rabelo Ana Lúcia R. Nascimento Alan Cesar N. Moraes Andressa Bernardi Fernanda V. Guimarães Gabriela M. Carvalho Jemima F. R. da Silva Jorge J. de Carvalho |
| author_facet | Priscila G. Pereira Luciana L. Alves Bianca T. Ciambarella Kíssila Rabelo Ana Lúcia R. Nascimento Alan Cesar N. Moraes Andressa Bernardi Fernanda V. Guimarães Gabriela M. Carvalho Jemima F. R. da Silva Jorge J. de Carvalho |
| author_sort | Priscila G. Pereira |
| collection | DOAJ |
| description | Obesity is an inflammatory disease associated with secondary diseases such as kidney disease, which can cause lipotoxicity, inflammation and loss of organ function. Polyunsaturated fatty acids act in the production of lipid mediators and have anti-inflammatory characteristics. In this work, the objective was to evaluate renal histopathology in obese mice and the effects of treatment with capybara oil (CO) (5000 mg/kg/day for 4 weeks). Parameters such as body mass, lipid profile, systolic blood pressure, urinary creatinine and protein excretion, structure and ultrastructure of the renal cortex, fibrosis, tissue inflammation and oxidative stress were analyzed. CO treatment in obese mice showed improvement in the lipid profile and reduction in systolic blood pressure levels, in addition to beneficial remodeling of the renal cortex. Our data demonstrated that CO decreased inflammation, oxidative stress and renal fibrosis, as evidenced by quantifying the expression of TNF-α, IL-10, CAT, SOD, α-SMA and TGF-β. Although treatment with CO did not show improvement in renal function, ultrastructural analysis showed that the treatment was effective in restoring podocytes and pedicels, with restructuring of the glomerular filtration barrier. These results demonstrate, for the first time, that treatment with CO is effective in reducing kidney damage, being considered a promising treatment for obesity. |
| first_indexed | 2024-03-11T01:32:11Z |
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| language | English |
| last_indexed | 2024-03-11T01:32:11Z |
| publishDate | 2023-06-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-45f640bf5d364ee396ae110d4408df762023-11-18T17:14:29ZengMDPI AGNutrients2072-66432023-06-011513292510.3390/nu15132925Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese MicePriscila G. Pereira0Luciana L. Alves1Bianca T. Ciambarella2Kíssila Rabelo3Ana Lúcia R. Nascimento4Alan Cesar N. Moraes5Andressa Bernardi6Fernanda V. Guimarães7Gabriela M. Carvalho8Jemima F. R. da Silva9Jorge J. de Carvalho10Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilElectron Microscopy Laboratory of Biology Institute, University of Federal Fluminense, Rio de Janeiro 21040-900, RJ, BrazilInflammation Laboratory, Fiocruz, Rio de Janeiro 21040-900, RJ, BrazilInflammation Laboratory, Fiocruz, Rio de Janeiro 21040-900, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilUltrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, BrazilObesity is an inflammatory disease associated with secondary diseases such as kidney disease, which can cause lipotoxicity, inflammation and loss of organ function. Polyunsaturated fatty acids act in the production of lipid mediators and have anti-inflammatory characteristics. In this work, the objective was to evaluate renal histopathology in obese mice and the effects of treatment with capybara oil (CO) (5000 mg/kg/day for 4 weeks). Parameters such as body mass, lipid profile, systolic blood pressure, urinary creatinine and protein excretion, structure and ultrastructure of the renal cortex, fibrosis, tissue inflammation and oxidative stress were analyzed. CO treatment in obese mice showed improvement in the lipid profile and reduction in systolic blood pressure levels, in addition to beneficial remodeling of the renal cortex. Our data demonstrated that CO decreased inflammation, oxidative stress and renal fibrosis, as evidenced by quantifying the expression of TNF-α, IL-10, CAT, SOD, α-SMA and TGF-β. Although treatment with CO did not show improvement in renal function, ultrastructural analysis showed that the treatment was effective in restoring podocytes and pedicels, with restructuring of the glomerular filtration barrier. These results demonstrate, for the first time, that treatment with CO is effective in reducing kidney damage, being considered a promising treatment for obesity.https://www.mdpi.com/2072-6643/15/13/2925obesitykidney injurycapybara oilomega-3inflammationfibrosis |
| spellingShingle | Priscila G. Pereira Luciana L. Alves Bianca T. Ciambarella Kíssila Rabelo Ana Lúcia R. Nascimento Alan Cesar N. Moraes Andressa Bernardi Fernanda V. Guimarães Gabriela M. Carvalho Jemima F. R. da Silva Jorge J. de Carvalho Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice Nutrients obesity kidney injury capybara oil omega-3 inflammation fibrosis |
| title | Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice |
| title_full | Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice |
| title_fullStr | Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice |
| title_full_unstemmed | Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice |
| title_short | Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice |
| title_sort | capybara oil improves renal pathophysiology and inflammation in obese mice |
| topic | obesity kidney injury capybara oil omega-3 inflammation fibrosis |
| url | https://www.mdpi.com/2072-6643/15/13/2925 |
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